Spatial and temporal effects in speckle perfusion measurement

O. B. Thompson; M. K. Andrews

doi:10.1117/12.807901

12 February 2009 Spatial and temporal effects in speckle perfusion measurement

O. B. Thompson, M. K. Andrews

Proceedings Volume 7176, Dynamics and Fluctuations in Biomedical Photonics VI; 717604 (2009) https://doi.org/10.1117/12.807901
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Laser speckle contrast techniques have been increasingly applied to dermal perfusion measurements over the past few years. The interpretation of laser speckle contrast and its conversion to a physiologically-defined perfusion parameter related to that found from Doppler measurements is becoming clearer. Speckle contrast-based techniques provide both quantified perfusion images and a time-series record of perfusion. We use the image resolution available in speckle measurements to investigate spatial resolution which can be expected in tissue; in particular to reconcile speckle measurements with the large point-to-point variations reported from fibre Doppler probes. In vitro models show the extent of spatial blurring likely to be encountered in speckle measurements at different depths. Perfusion responses related to vascular challenges could have medical relevance. We find a small pulse-related signal in dermal speckle data. By identifying pulses in a temporal record using a matched filter, we find statistical average pulse shapes for several different subjects, allowing comparison of pulsatile flow profiles between them. The profiles measured by this technique are repeatable on the same subject, and vary between subjects. At some body sites, notably near arterioles, the response obviously relates to gross tissue motion, but at others the signature is of dermal origin. It is not yet clear whether it relates to actual capillary flow variation or distortion of the scattering tissue in response to changes in the driving pressure.

Citation Download Citation

O. B. Thompson and M. K. Andrews "Spatial and temporal effects in speckle perfusion measurement", Proc. SPIE 7176, Dynamics and Fluctuations in Biomedical Photonics VI, 717604 (12 February 2009); https://doi.org/10.1117/12.807901

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available