Evaluation of toxicological properties and photodynamic activity of Photolon ointment: an experimental study

Siarhei V. Shliakhtsin; Tatsiana V. Trukhachova; Yuriy P. Istomin; Ludmila N. Dunetz; Andrey V. Kuvshinov; Semen A. Naumovich

doi:10.1117/12.823834

13 July 2009 Evaluation of toxicological properties and photodynamic activity of Photolon ointment: an experimental study

Siarhei V. Shliakhtsin, Tatsiana V. Trukhachova, Yuriy P. Istomin, Ludmila N. Dunetz, Andrey V. Kuvshinov, Semen A. Naumovich

Author Affiliations +

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 738040 (2009) https://doi.org/10.1117/12.823834
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

The purpose of the present study was to evaluate toxicological properties and photodynamic activity of a new ready form of the photosensitizer Photolon (Fotolon) - an ointment for topical use. The data obtained show the use of topicaly applied photosensitizer provides sufficient penetration and accumulation of the active compound in tumor tissue as well as in affected periodontal tissues for the effective PDT. There are several advantages of PDT with topical application of the photosensitizer such as absence of systemic toxic and photosensitive reactions, relatively low cost of the treatment and etc. We have shown that PDT of affected periodontal tissues with local application of Photolon/Fotolon ointment provides an ability of local destruction of microbial cell, located as on the gum surface as in the spatium intercellulare what is extremely important for successful treatment of acute and chronic periodontitis.

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Siarhei V. Shliakhtsin, Tatsiana V. Trukhachova, Yuriy P. Istomin, Ludmila N. Dunetz, Andrey V. Kuvshinov, and Semen A. Naumovich "Evaluation of toxicological properties and photodynamic activity of Photolon ointment: an experimental study", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738040 (13 July 2009); https://doi.org/10.1117/12.823834

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