Noninvasive laser coagulation of the canine vas deferens, in vivo

Christopher M. Cilip; Ashley E. Ross; Jonathan P. Jarow; Nathaniel M. Fried

doi:10.1117/12.839601

2 March 2010 Noninvasive laser coagulation of the canine vas deferens, in vivo

Christopher M. Cilip, Ashley E. Ross, Jonathan P. Jarow, Nathaniel M. Fried

Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75481D (2010) https://doi.org/10.1117/12.839601
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Development of a noninvasive vasectomy technique may eliminate male fear of complications (incision, bleeding, infection, and scrotal pain) and result in a more popular procedure. This study builds upon previously reported ex vivo tissue studies by exploring acute and short-term chronic in vivo canine studies. Isolation of the canine vas was achieved using a conventional vas ring clamp method. No perforation of the scrotal skin was necessary to occlude the vas. Laser radiation with a wavelength of 1075 nm, average power of 11.2 W, 500-ms pulse duration, 0.5 Hz pulse rate, and 3-mm-diameter spot was synchronized with cryogen spray cooling of the scrotal skin surface in a total of 8 dogs (n = 16 vasa) for a treatment time of 60 s. Burst pressure measurements were conducted at Days 0 and 21 (n = 8 vasa each day) to quantify the strength of vas closure. The vas was successfully thermally occluded in 15/16 (94%) procedures with 14/15 (93%) vas recording burst pressures above ejaculation pressure. One vas was not present, and another vas recorded a bursting pressure below ejaculation pressure. The coagulated vas bursting pressure averaged 283 ± 34 mm Hg at Day 0 and 260 ± 77 mm Hg at Day 21, significantly higher than reported vas ejaculation pressures of 136 ± 29 mm Hg. Minor scrotal skin burns were observed during the recovery period. Noninvasive thermal occlusion of the vas is feasible in an in vivo canine model. Elimination of minor skin burns and longer term chronic in vivo canine studies are needed to confirm azospermia after vas occlusion without recanalization.

Citation Download Citation

Christopher M. Cilip, Ashley E. Ross, Jonathan P. Jarow, and Nathaniel M. Fried "Noninvasive laser coagulation of the canine vas deferens, in vivo", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75481D (2 March 2010); https://doi.org/10.1117/12.839601

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