Development of an autofluorescent probe designed to help brain tumor removal: study on an animal model

R. Siebert; B. Leh; Y. Charon; M. Collado-Hilly; M.-A. Duval; L. Menard; F. P. Monnet; P. Varlet

doi:10.1117/12.841373

2 March 2010 Development of an autofluorescent probe designed to help brain tumor removal: study on an animal model

R. Siebert, B. Leh, Y. Charon, M. Collado-Hilly, M.-A. Duval, L. Menard, F. P. Monnet, P. Varlet

Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75483Y (2010) https://doi.org/10.1117/12.841373
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

The complete resection of the brain tumour is crucial to the patient life quality and prognosis. An autofluorescence probe aiming at helping the surgeon to improve the completeness of the removal is being developed. Autofluorescence spectroscopy is a promising approach to define whether the tissue is cancerous or not. First ex vivo measurements have been realised on an animal model. After tumorous cell injection in rat brain, autofluorescence intensity is revealed from the extracted brain. These autofluorescence data are compared to results from a histological analysis of same brains. First indicators are identified that may have the ability to differentiate tumorous and healthy tissues.

Citation Download Citation

R. Siebert, B. Leh, Y. Charon, M. Collado-Hilly, M.-A. Duval, L. Menard, F. P. Monnet, and P. Varlet "Development of an autofluorescent probe designed to help brain tumor removal: study on an animal model", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75483Y (2 March 2010); https://doi.org/10.1117/12.841373

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