Treatment feasibility study of osteoporosis using minimal invasive laser needle system

Dongyeon Kang; Chang-Yong Ko; Yeon-Hang Ryu; Sunwook Park; Han-Sung Kim; Byungjo Jung

doi:10.1117/12.843088

2 March 2010 Treatment feasibility study of osteoporosis using minimal invasive laser needle system

Dongyeon Kang, Chang-Yong Ko, Yeon-Hang Ryu, Sunwook Park, Han-Sung Kim, Byungjo Jung

Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75484C (2010) https://doi.org/10.1117/12.843088
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Although the mechanism of laser stimulation effect in bone has not completely understood, laser stimulation is recommended in the treatment of osteoporosis due to positive treatment efficacy. In this study, a minimal invasive laser needle system (MILNS) was developed using a fine hollow needle in order to stimulate directly bone site by guiding an optical fiber. In order to evaluate the MILNS as a treatment method, in-vivo animal experiment study was performed using osteopenic mice. Twelve virginal ICR mice were employed and divided two groups: SHAM-group and LASERgroup. SHARM-group was stimulated by only fine hollow needle and LASER-group by fine hollow needle combined with laser stimulation. All mice were served in-vivo micro-CT images before and after treatment. Three dimensional (3D) structural parameters and vBMD (volume bone mineral density, g/cm3) in the trabecular bone were measured. After 2 weeks of stimulation, the vBMD, BV/TV, Tb.Th and Tb.N in LASER-group were significantly higher than those in SHAM-group (p<0.05). Potentially, this study suggested that the MILNS might prevent the bone loss and maintains the bone mineral density of osteopenic mice.

Citation Download Citation

Dongyeon Kang, Chang-Yong Ko, Yeon-Hang Ryu, Sunwook Park, Han-Sung Kim, and Byungjo Jung "Treatment feasibility study of osteoporosis using minimal invasive laser needle system", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75484C (2 March 2010); https://doi.org/10.1117/12.843088

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