Investigation of protein aggregation dynamics with a Bloch surface wave sensor

Vincent Paeder; Sara Santi; Valeria Musi; Hans Peter Herzig

doi:10.1117/12.889698

14 June 2011 Investigation of protein aggregation dynamics with a Bloch surface wave sensor

Vincent Paeder, Sara Santi, Valeria Musi, Hans Peter Herzig

Proceedings Volume 8090, Novel Biophotonic Techniques and Applications; 80900C (2011) https://doi.org/10.1117/12.889698
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

We present a study of the dynamics of protein aggregation using a common path heterodyne Bloch surface wave sensing scheme. We demonstrate the ability to detect, during thermal incubation, the early events linked to the aggregation of proteins related to conformational diseases. Alzheimer's amyloid-β 1-42 is used to demonstrate the efficiency of the method. A model based on elementary interactions is shown to describe accurately the aggregation process. The described sensing scheme is sensitive to the early events of the aggregation process. is hence proposed as a method for the detection of early stages of the evolution of conformational diseases.

Citation Download Citation

Vincent Paeder, Sara Santi, Valeria Musi, and Hans Peter Herzig "Investigation of protein aggregation dynamics with a Bloch surface wave sensor", Proc. SPIE 8090, Novel Biophotonic Techniques and Applications, 80900C (14 June 2011); https://doi.org/10.1117/12.889698

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