A combined time-domain diffuse fluorescence and optical tomography system for breast tumor detection

Wei Zhang; Feng Gao; Linhui Wu; Wenjuan Ma; Yiming Lu; Zhongxing Zhou

doi:10.1117/12.907066

28 February 2012 A combined time-domain diffuse fluorescence and optical tomography system for breast tumor detection

Wei Zhang, Feng Gao, Linhui Wu, Wenjuan Ma, Yiming Lu, Zhongxing Zhou

Proceedings Volume 8214, Advanced Biomedical and Clinical Diagnostic Systems X; 82141B (2012) https://doi.org/10.1117/12.907066
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

A combined time-domain diffuse fluorescence and optical tomographic system is proposed based on the multi-channel time-correlated single-photon counting (TCSPC) technique, aiming at enhancing the reliability of breast diffuse optical tomography. The system equipped with two pulsed laser diodes at wavelengths of 780 nm and 830 nm that are specific to the maximal excitation and emission of the FDA-approved ICG dye, and works with a 4-channel TCSPC module to acquire the temporal distributions of the light re-emissions 32 boundary sites of tissues in a tandem serial-to-parallel mode. The performance and efficacy of the system are investigated with phantom experiments for diffuse optical tomography (DOT), as well as fluorescence-guided DOT.

Citation Download Citation

Wei Zhang, Feng Gao, Linhui Wu, Wenjuan Ma, Yiming Lu, and Zhongxing Zhou "A combined time-domain diffuse fluorescence and optical tomography system for breast tumor detection", Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 82141B (28 February 2012); https://doi.org/10.1117/12.907066

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
11 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Luminescence

Absorption

Breast

Data acquisition

Diffuse optical tomography

Optical tomography

Calibration

Show All Keywords

Keywords/Phrases

Search In:

Publication Years