Comparing the micro-vascular structure of cancerous and healthy tissues

Bert Müller; Sabrina Lang; Felix Beckmann; Marco Dominietto; Markus Rudin; Irene Zanette; Timm Weitkamp; Alexander Rack; Simone Elke Hieber

doi:10.1117/12.929941

17 October 2012 Comparing the micro-vascular structure of cancerous and healthy tissues

Bert Müller, Sabrina Lang, Felix Beckmann, Marco Dominietto, Markus Rudin, Irene Zanette, Timm Weitkamp, Alexander Rack, Simone Elke Hieber

Author Affiliations +

Proceedings Volume 8506, Developments in X-Ray Tomography VIII; 850607 (2012) https://doi.org/10.1117/12.929941
Event: SPIE Optical Engineering + Applications, 2012, San Diego, California, United States

Abstract

Basic research is required to develop more powerful approaches to prevent, diagnose, and above all to treat cancer, although the clever combination of surgery, chemical, pharmacological, and radiation therapies is well established. Our research activity concentrates on the quantification of the three-dimensional micro-morphology of vessel trees formed in cancerous and healthy tissues of a mouse model post mortem. While in several cases it is possible to extract the vessel tree from corrosion casts, phase contrast imaging modalities are needed for cancerous tissues with a significant amount of damaged vessel walls. Differences between cancerous and healthy tissues could be identified. The sum-of-angle metrics is found to be constant for vessel segments in cancerous and healthy tissues with lengths between 12 and 220 μm and corresponds to (0.62 ± 0.10) rad/μm.

Citation Download Citation

Bert Müller, Sabrina Lang, Felix Beckmann, Marco Dominietto, Markus Rudin, Irene Zanette, Timm Weitkamp, Alexander Rack, and Simone Elke Hieber "Comparing the micro-vascular structure of cancerous and healthy tissues", Proc. SPIE 8506, Developments in X-Ray Tomography VIII, 850607 (17 October 2012); https://doi.org/10.1117/12.929941

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