Microwave tumor ablation: cooperative academic-industry development of a high-power gas-cooled system with early clinical
results

Christopher L. Brace; Timothy J. Ziemlewicz; Rick Schefelker; J. Louis Hinshaw; Meghan G. Lubner; Fred T. Lee Jr.

doi:10.1117/12.2004094

26 February 2013 Microwave tumor ablation: cooperative academic-industry development of a high-power gas-cooled system with early clinical results

Christopher L. Brace, Timothy J. Ziemlewicz, Rick Schefelker, J. Louis Hinshaw, Meghan G. Lubner, Fred T. Lee Jr.

Author Affiliations +

Proceedings Volume 8584, Energy-based Treatment of Tissue and Assessment VII; 858405 (2013) https://doi.org/10.1117/12.2004094
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Microwave tumor ablation continues to evolve into a viable treatment option for many cancers. Current systems are poised to supplant radiofrequency ablation as the dominant percutaneous thermal therapy. Here is provided an overview of technical details and early clinical results with a high-powered, gas-cooled microwave ablation system. The system was developed with academic-industry collaboration using federal and private funding. The generator comprises three synchronous channels that each produce up to 140W at 2.45GHz. A mountable power distribution module facilitates CT imaging guidance and monitoring and reduces clutter in the sterile field. Cryogenic carbon-dioxide cools the coaxial applicator, permitting a thin applicator profile (~1.5 mm diameter) and high power delivery. A total of 106 liver tumors were treated (96 malignant, 10 benign) from December 2010 to June 2012 at a single academic institution. Mean tumor size ± standard deviation was 2.5±1.3cm (range 0.5-13.9cm). Treatment time was 5.4±3.3min (range 1-20min). Median follow-up was 6 months (range 1-16 months). Technical success was reported in 100% of cases. Local tumor progression was noted in 4/96 (4.3%) of malignancies. The only major complication was a pleural effusion that was treated with thoracentesis. Microwave ablation with this system is an effective treatment for liver cancer. Compared to previous data from the same institution, these results suggest an increased efficacy and equivalent safety to RF ablation. Additional data from the lung and kidney support this conclusion.

Citation Download Citation

Christopher L. Brace, Timothy J. Ziemlewicz, Rick Schefelker, J. Louis Hinshaw, Meghan G. Lubner, and Fred T. Lee Jr. "Microwave tumor ablation: cooperative academic-industry development of a high-power gas-cooled system with early clinical results", Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 858405 (26 February 2013); https://doi.org/10.1117/12.2004094

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KEYWORDS

Microwave radiation

Tumors

Antennas

Tissues

Liver

Lung

Cancer

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