Dual energy iodine contrast imaging with mammography and tomosynthesis

Baorui Ren; Chris Ruth; Yiheng Zhang; Andrew Smith; Don Kennedy; Bernadette O'Keefe; Ian Shaw; Cornell Williams; Zhen Ye; Elena Ingal; Brad Polischuk; Zhenxue Jing

doi:10.1117/12.2008147

19 March 2013 Dual energy iodine contrast imaging with mammography and tomosynthesis

Baorui Ren, Chris Ruth, Yiheng Zhang, Andrew Smith, Don Kennedy, Bernadette O'Keefe, Ian Shaw, Cornell Williams, Zhen Ye, Elena Ingal, Brad Polischuk, Zhenxue Jing

Author Affiliations +

Proceedings Volume 8668, Medical Imaging 2013: Physics of Medical Imaging; 86680U (2013) https://doi.org/10.1117/12.2008147
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

We have developed dual energy (DE) iodine contrast imaging functions with a commercial mammography and tomosynthesis system. Our system uses a tungsten target x-ray tube and selenium direct conversion detector. Conventional low energy (LE) images were acquired with existing Rh, Ag and Al filters at the screening doses while the high energy images (HE) were acquired with new Cu filters at half of the screening doses. In DE 2D mode, a pair of LE and HE images was taken with one second delay time between and with anti-scatter grid. In DE 3D mode, 22 views of alternating LE and HE were taken over 15 degrees angle in seven seconds without grid while tube was scanned continuously. We used log-subtraction algorithm to obtain clean DE images with the subtraction factor K derived empirically. In 3D mode, the subtraction was applied to each pair of LE and HE slices after reconstruction. The x-ray technique optimization was done with simulation and phantom study. We performed both phantom and patient studies to demonstrate the advantage of iodine contrast imaging. Among several new things in our work, a selenium detector optimized for DE imaging was tested and a large dose advantage was demonstrated; 2D and 3D DE images of a breast under same compression were acquired with a unique DE combo mode of the system, allowing direct image quality comparison between 2D and 3D modes. Our study showed that new DE system achieved good image quality. DE imaging is be a promising modality to detect breast cancer.

Citation Download Citation

Baorui Ren, Chris Ruth, Yiheng Zhang, Andrew Smith, Don Kennedy, Bernadette O'Keefe, Ian Shaw, Cornell Williams, Zhen Ye, Elena Ingal, Brad Polischuk, and Zhenxue Jing "Dual energy iodine contrast imaging with mammography and tomosynthesis", Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86680U (19 March 2013); https://doi.org/10.1117/12.2008147

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