Using micro-Raman spectroscopy for nasopharyngeal cancerous tissue detection

Shanshan Wu; Liqing Sun; Maowen Chen; Jia Lin; Gang Cao; Wei Huang; Rong Chen

doi:10.1117/12.2069229

17 September 2014 Using micro-Raman spectroscopy for nasopharyngeal cancerous tissue detection

Shanshan Wu, Liqing Sun, Maowen Chen, Jia Lin, Gang Cao, Wei Huang, Rong Chen

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 923028 (2014) https://doi.org/10.1117/12.2069229
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Micro-Raman spectroscopy is widely used for non-invasive tissue diagnosis and detection, as it provides detailed information about biomolecular composition, structure, and interaction of tissue. In this work, micro-Raman spectroscopy was used to investigate non-cancerous and cancerous nasopharyngeal tissues. The obtained nasopharyngeal tissue samples in vitro are divided into two groups: cancerous (n=12, undifferentiated non-keratinizing carcinomas) and non-cancerous (n=10, 7 chronic inflammations, 2 lymphomas and 1 lymphocytosis). Firstly, we analyzed the Raman spectra in the fingerprint (FP, 400-1800cm^-1)region acquired. Preliminary results showed that there are some spectral differences in different pathological conditions. Furthermore, Raman spectra from cancerous and non-cancerous nasopharyngeal tissue in the high wavenumber region (HW, 2800-3100cm^-1) were also reported for the first time. After detailed analysis, we achieved significant differences in Raman bands at 2854, 2874, 2934, and 3067cm^-1 between cancerous and non-cancerous nasopharyngeal tissues. This study demonstrates that both fingerprint and high wavenumber regions of micro-Raman spectroscopy have the potential for the early detection of nasopharyngeal carcinomas.

Citation Download Citation

Shanshan Wu, Liqing Sun, Maowen Chen, Jia Lin, Gang Cao, Wei Huang, and Rong Chen "Using micro-Raman spectroscopy for nasopharyngeal cancerous tissue detection", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923028 (17 September 2014); https://doi.org/10.1117/12.2069229

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Raman spectroscopy

Tissues

Tissue optics

Micro raman spectroscopy

Cancer

Diagnostics

Computed tomography

Show All Keywords

Keywords/Phrases

Search In:

Publication Years