Innovative parameters obtained for digital analysis of microscopic images to evaluate in vitro hemorheological action of anesthetics

Analía I. Alet; Sabrina Basso; Marcela Delannoy; Nicolás A. Alet; Mabel D'Arrigo; Horacio V. Castellini; Bibiana D. Riquelme

doi:10.1117/12.2180791

19 June 2015 Innovative parameters obtained for digital analysis of microscopic images to evaluate in vitro hemorheological action of anesthetics

Analía I. Alet, Sabrina Basso, Marcela Delannoy, Nicolás A. Alet, Mabel D'Arrigo, Horacio V. Castellini, Bibiana D. Riquelme

Author Affiliations +

Proceedings Volume 9531, Biophotonics South America; 95311P (2015) https://doi.org/10.1117/12.2180791
Event: SPIE Biophotonics South America, 2015, Rio de Janeiro, Brazil

Abstract

Drugs used during anesthesia could enhance microvascular flow disturbance, not only for their systemic cardiovascular actions but also by a direct effect on the microcirculation and in particular on hemorheology. This is particularly important in high-risk surgical patients such as those with vascular disease (diabetes, hypertension, etc.). Therefore, in this work we propose a set of innovative parameters obtained by digital analysis of microscopic images to study the in vitro hemorheological effect of propofol and vecuronium on red blood cell from type 2 diabetic patients compared to healthy donors. Obtained innovative parameters allow quantifying alterations in erythrocyte aggregation, which can increase the in vivo risk of microcapillary obstruction.

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Analía I. Alet, Sabrina Basso, Marcela Delannoy, Nicolás A. Alet, Mabel D'Arrigo, Horacio V. Castellini, and Bibiana D. Riquelme "Innovative parameters obtained for digital analysis of microscopic images to evaluate in vitro hemorheological action of anesthetics", Proc. SPIE 9531, Biophotonics South America, 95311P (19 June 2015); https://doi.org/10.1117/12.2180791

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