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7 March 2022 Foveal cone optoretinography using a reflective mirror-based line-scan adaptive optics OCT
Vimal Prabhu Pandiyan, Sierra Schleufer, Xiaoyun Jiang, James Kuchenbecker, Ramkumar Sabesan
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Proceedings Volume PC11941, Ophthalmic Technologies XXXII; PC119410F (2022) https://doi.org/10.1117/12.2610421
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
We introduce reflective mirror-based line-scan adaptive optics line-scan OCT, optimized for imaging light-induced retinal activity (optoretinography) and weak retinal reflections at the cellular scale. The performance was exemplified by cellular-scale visualization of retinal ganglion cells, macrophages, foveal cones, and rods in human observers. Light-evoked optical changes in foveal cones were observable at an eccentricity 0.3 deg. from the foveal center, enabling the first in vivo demonstration of reduced S-cone (short-wavelength cone) density in the human foveola. Given the challenges typically associated with optical accessibility in the living human fovea, this instrument holds significant promise for basic and translational applications.
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Vimal Prabhu Pandiyan, Sierra Schleufer, Xiaoyun Jiang, James Kuchenbecker, and Ramkumar Sabesan "Foveal cone optoretinography using a reflective mirror-based line-scan adaptive optics OCT", Proc. SPIE PC11941, Ophthalmic Technologies XXXII, PC119410F (7 March 2022); https://doi.org/10.1117/12.2610421
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KEYWORDS
Line scan image sensors
Optical coherence tomography
Adaptive optics
Reflectivity
Retinal scanning
Image resolution
In vivo imaging
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