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17 March 2023 Fluorescence spectroscopy based estimation of biochemical concentrations and scattering properties for colorectal cancer detection
Marcelo Saito Nogueira, Robert Matthews, Shane Killeen, Micheal O'Riordain, Stefan Andersson-Engels
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Proceedings Volume PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; PC1236108 (2023) https://doi.org/10.1117/12.2650441
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Colorectal cancer (CRC) is the third most common and the second most deadly type of cancer worldwide. Currently, early-stage CRC detection is hindered by the limited information gold standard screening and diagnostic procedures (colonoscopies) provide on tissue structural changes. Accuracy of early CRC detection during colonoscopy and CRC delineation during microsurgery can potentially be increased by adding tissue molecular information in real-time. We developed a molecular-sensitive tool capable of determining depth-resolved fluorophore and chromophore concentrations, as well as scattering properties from wavelength-resolved fluorescence spectra alone. Normal mucosa and CRC exhibited differences in elastin, flavin, bile and lipid concentrations.
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Marcelo Saito Nogueira, Robert Matthews, Shane Killeen, Micheal O'Riordain, and Stefan Andersson-Engels "Fluorescence spectroscopy based estimation of biochemical concentrations and scattering properties for colorectal cancer detection", Proc. SPIE PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, PC1236108 (17 March 2023); https://doi.org/10.1117/12.2650441
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KEYWORDS
Error control coding
Colorectal cancer
Scattering
Tissues
Biological research
Fluorescence spectroscopy
Mie scattering
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