Evolution of polarimetric parameters of cadaver brain tissue with time and formaldehyde fixation in wide-field Mueller matrix images (Conference Presentation)

Romain Gros; Leonard A. Felger; Theoni Maragkou; Richard Mckinley; Stefano Moriconi; Michael Murek; Tatiana Novikova; Omar Rodríguez-Núñez; Philippe Schucht; Irena Zubak; Angelo Pierangelo

doi:10.1117/12.2645668

15 March 2023 Evolution of polarimetric parameters of cadaver brain tissue with time and formaldehyde fixation in wide-field Mueller matrix images (Conference Presentation)

Romain Gros, Leonard A. Felger, Theoni Maragkou, Richard Mckinley, Stefano Moriconi, Michael Murek, Tatiana Novikova, Omar Rodríguez-Núñez, Philippe Schucht, Irena Zubak, Angelo Pierangelo

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Proceedings Volume PC12382, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023; PC1238203 (2023) https://doi.org/10.1117/12.2645668
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Surgical resection is the first-line treatment for most malignancies of the brain. However, the intraoperative identification of brain tumor tissue remains a challenge. In previous work, we demonstrated the potential of wide-field Mueller Polarimetric Imaging (MPI) to assess the anisotropy of fresh and fixed specimens of healthy brain, independently. Now, we use the MPI system to acquire polarimetric maps of fresh cadaveric pig cerebral tissue and compare the parameter evolution over time following formaldehyde-fixation. We demonstrated that despite the apparition of tissue morphological changes induced by formaldehyde fixation, this process preserves the polarimetric properties, remaining quantitatively similar to fresh tissue ones.

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Romain Gros, Leonard A. Felger, Theoni Maragkou, Richard Mckinley, Stefano Moriconi, Michael Murek, Tatiana Novikova, Omar Rodríguez-Núñez, Philippe Schucht, Irena Zubak, and Angelo Pierangelo "Evolution of polarimetric parameters of cadaver brain tissue with time and formaldehyde fixation in wide-field Mueller matrix images (Conference Presentation)", Proc. SPIE PC12382, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023, PC1238203 (15 March 2023); https://doi.org/10.1117/12.2645668

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KEYWORDS

Brain

Tissues

Tissue optics

Polarimetry

Neuroimaging

Statistical analysis

Anisotropy

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