Purpose: We report that a large field-of-view (FOV) retinal image can be acquired by a smart fundus camera.

Approach: This handheld system consists of a Raspberry Pi board, a touch screen display, a customized optical lens group, a ring light-emitting diode, and a Li-battery.

Results: Wide FOV of ∼57  deg is observed with proper lens configuration and can be expanded using image stitching algorithms.

Conclusions: This customized handheld fundus camera provides better image quality than cellphone-based fundus imaging solutions and offers more operational features than traditional portable fundus cameras. It may benefit field-portable ophthalmic diagnostic applications.