Distinguishing ectopic placental calcification with multi-parametric ultrasound and photoacoustic imaging

Skye A. Edwards; Deeksha Sankepalle; Ana Branco; Mary C Wallingford; Srivalleesha Mallidi

doi:10.1117/12.2650611

9 March 2023 Distinguishing ectopic placental calcification with multi-parametric ultrasound and photoacoustic imaging

Skye A. Edwards, Deeksha Sankepalle, Ana Branco, Mary C Wallingford, Srivalleesha Mallidi

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC1237918 (2023) https://doi.org/10.1117/12.2650611
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

As medical advances allow the maternal age to rise, the risk of ectopic calcification and placental vascular dysfunction increases, both associated with preeclampsia. We investigated Slc20a2 mice models through non-invasive commercial ultrasound and photoacoustic imaging. This model exhibits increased ectopic placental vascular calcification, reduced fetal growth, and decreased postnatal bone mineral density. Our experiments established a significant difference in both placental function and structural differences between normal and diseased placentas. Dual-wavelength images and radio frequency data provided oxygen saturation and quantitative ultrasound spectral parameters that proved the control placentas can be distinguished from knockout placentas.

Conference Presentation

Citation Download Citation

Skye A. Edwards, Deeksha Sankepalle, Ana Branco, Mary C Wallingford, and Srivalleesha Mallidi "Distinguishing ectopic placental calcification with multi-parametric ultrasound and photoacoustic imaging", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC1237918 (9 March 2023); https://doi.org/10.1117/12.2650611

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