Photoacoustic imaging of the hemodynamic responses in the mouse brain induced by retinal photostimulation

Kai-Wei Chang; Xueding Wang; Kwoon Y. Wong; Guan Xu

doi:10.1117/12.3001911

13 March 2024 Photoacoustic imaging of the hemodynamic responses in the mouse brain induced by retinal photostimulation

Kai-Wei Chang, Xueding Wang, Kwoon Y. Wong, Guan Xu

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128420Q (2024) https://doi.org/10.1117/12.3001911
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

This study uses a label-free photoacoustic computed tomography (PACT) system with a linear ultrasound transducer array to monitor the visual-evoked hemodynamic responses in the mouse brain. Acoustic signals were collected during retinal photostimulation, utilizing flickering white light. The observed hemodynamic responses occurred in the primary visual cortex (V1), superior colliculus (SC), lateral geniculate nucleus (LGd), olivary pretectal nucleus (OPN), and suprachiasmatic nucleus (SCN). Response magnitudes and latencies were compared between wild-type, retinal degeneration (rd1), and melanopsin knock-out mice, illustrating the potential of our PACT system in studying brain activities related to retinal diseases.

Conference Presentation

Citation Download Citation

Kai-Wei Chang, Xueding Wang, Kwoon Y. Wong, and Guan Xu "Photoacoustic imaging of the hemodynamic responses in the mouse brain induced by retinal photostimulation", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128420Q (13 March 2024); https://doi.org/10.1117/12.3001911

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