Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels

Molly J. Rossow; William W. Mantulin; Enrico Gratton

doi:10.1117/1.3088203

1 March 2009 Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels

Molly J. Rossow, William W. Mantulin, Enrico Gratton

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Journal of Biomedical Optics, Vol. 14, Issue 2, 024014 (March 2009). https://doi.org/10.1117/1.3088203

Abstract

Accurate blood flow measurements during surgery can improve an operation's chance of success. We developed near-infrared spatio-temporal image spectroscopy (NIR-STICS), which has the potential to make blood flow measurements that are difficult to accomplish with existing methods. Specifically, we propose the technique and we show feasibility on phantom measurements. NIR-STICS has the potential of measuring the fluid velocity in small blood vessels (less than 1 mm in diameter) and of creating a map of blood flow rates over an area of approximately 1 cm². NIR-STICS employs near-infrared spectroscopy to probe inside blood vessel walls and spatiotemporal image correlation spectroscopy to directly-without the use of a model-extract fluid velocity from the fluctuations within an image. We present computer simulations and experiments on a phantom system that demonstrate the effectiveness of NIR-STICS.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Molly J. Rossow, William W. Mantulin, and Enrico Gratton "Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels," Journal of Biomedical Optics 14(2), 024014 (1 March 2009). https://doi.org/10.1117/1.3088203

Published: 1 March 2009

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