Dr. Enrico Gratton Profile

Dr. Enrico Gratton

Professor at Univ of California Irvine

SPIE Involvement:

Author

Publications (96)

Proceedings Article | 13 March 2024 Presentation

Advancing optical metabolic imaging through phasor-based S-FLIM-SHG microscopy

Belen Torrado, Alexander Vallmitjana, Michelle Digman, Alexander Dvornikov, Enrico Gratton

Proceedings Volume PC12847, PC128470R (2024) https://doi.org/10.1117/12.3009991

KEYWORDS: Optical imaging, Microscopy, Second harmonic generation, Microscopes, Fluorescence lifetime imaging, Ultraviolet radiation, Photons, Photobleaching, Multiphoton fluorescence microscopy, Molecules

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Proceedings Article | 9 March 2020 Open Access

Spectral phasors by the sin-cos filter method in a two-photon excitation microscope (Conference Presentation)

Enrico Gratton, Alexander Dvornikov

Proceedings Volume 11244, 1124404 (2020) https://doi.org/10.1117/12.2546619

KEYWORDS: Optical filters, Microscopes, Prisms, Modulation, Scattering, Tissues, Hyperspectral imaging, Luminescence, Cameras, Imaging systems

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Proceedings Article | 13 February 2020 Paper

Nano-resolution in vivo 3D orbital tracking system to study cellular dynamics and bio-molecular processes

Ulas Coskun, Matthew Ferguson, Alexander Vallmitjana, Anh Huynh, Julianna Goelzer, Yuansheng Sun, Shih-Chu Liao, Sunil Shah, Enrico Gratton, Beniamino Barbieri

Proceedings Volume 11246, 1124614 (2020) https://doi.org/10.1117/12.2546690

KEYWORDS: Particles, Microscopes, Luminescence, Molecules, Microscopy, Confocal microscopy, In vivo imaging, Diffusion, Stimulated emission depletion microscopy

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Proceedings Article | 14 March 2018 Open Access

Spectroscopic signatures of cells metabolism and extracellular species using phasor-FLIM (Conference Presentation)

Enrico Gratton

Proceedings Volume 10498, 1049803 (2018) https://doi.org/10.1117/12.2295142

KEYWORDS: Mode conditioning cables, Spectroscopy, Image visualization, Luminescence, Data analysis, Visual analytics, Visualization, Image analysis, Molecules, Image processing

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SPIE Journal Paper | 18 April 2016 Open Access

Label-free identification of macrophage phenotype by fluorescence lifetime imaging microscopy

Alba Alfonso-García, Tim Smith, Rupsa Datta, Thuy Luu, Enrico Gratton, Eric Potma, Wendy Liu

JBO, Vol. 21, Issue 04, 046005, (April 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.4.046005

KEYWORDS: Fluorescence lifetime imaging, Luminescence, Microscopy, Mode conditioning cables, Indium oxide, Laser phosphor displays, Visualization, Tissues, Biological research, Statistical analysis

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Proceedings Article | 22 February 2013 Paper

Ultra-deep imaging of turbid samples by enhanced photon harvesting

Viera Crosignani, Alexander Dvornikov, Enrico Gratton

Proceedings Volume 8588, 858810 (2013) https://doi.org/10.1117/12.2002101

KEYWORDS: Second-harmonic generation, Luminescence, Imaging systems, Fluorescence lifetime imaging, Tissues, Collagen, Tissue optics, Microscopes, Microscopy, Scattering

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SPIE Journal Paper | 12 December 2012 Open Access

Two-photon excited fluorescence lifetime imaging and spectroscopy of melanins in vitro and in vivo

Tatiana Krasieva, Chiara Stringari, Feng Liu, Chung-Ho Sun, Yu Kong, Mihaela Balu, Frank Meyskens, Enrico Gratton, Bruce Tromberg

JBO, Vol. 18, Issue 03, 031107, (December 2012) https://doi.org/10.1117/12.10.1117/1.JBO.18.3.031107

KEYWORDS: Fluorescence lifetime imaging, Luminescence, Skin, In vivo imaging, Fluorescence spectroscopy, Imaging spectroscopy, Spectroscopy, In vitro testing, Melanoma, Microscopy

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SPIE Journal Paper | 11 December 2012 Open Access

Phase synchronization of oxygenation waves in the frontal areas of children with attention-deficit hyperactivity disorder detected by optical diffusion spectroscopy correlates with medication

Sharon Wigal, Chiara Polzonetti, Annamarie Stehli, Enrico Gratton

JBO, Vol. 17, Issue 12, 127002, (December 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.12.127002

KEYWORDS: Brain, Near infrared spectroscopy, Hemodynamics, Absorption, Biomedical optics, Spectroscopy, Magnesium, Diffusion, Optical spectroscopy, Neuroimaging

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SPIE Journal Paper | 8 November 2012 Open Access

Deep tissue fluorescence imaging and in vivo biological applications

Viera Crosignani, Alexander Dvornikov, Jose Aguilar, Chiara Stringari, Robert Edwards, William Mantulin, Enrico Gratton

JBO, Vol. 17, Issue 11, 116023, (November 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.11.116023

KEYWORDS: Luminescence, Photons, In vivo imaging, Tissues, Tissue optics, Colon, Sensors, Stem cells, Intestine, Microscopes

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SPIE Journal Paper | 14 September 2012 Open Access

Digital parallel frequency-domain spectroscopy for tissue imaging

Cosimo Arnesano, Ylenia Santoro, Enrico Gratton

JBO, Vol. 17, Issue 9, 096014, (September 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.9.096014

KEYWORDS: Imaging spectroscopy, Modulation, Tissue optics, Reflectivity, Spectroscopy, Optical properties, Absorption, Phase measurement, Phase shift keying, Scattering

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SPIE Journal Paper | 20 April 2012 Open Access

Label-free separation of human embryonic stem cells and their differentiating progenies by phasor fluorescence lifetime microscopy

Chiara Stringari, Robert Sierra, Peter Donovan, Enrico Gratton

JBO, Vol. 17, Issue 04, 046012, (April 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.4.046012

KEYWORDS: Fluorescence lifetime imaging, Stem cells, Luminescence, In vitro testing, Image transmission, Microscopy, Biological research, Tissues, Mode conditioning cables, Modulation

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Proceedings Article | 9 February 2012 Paper

Phasor FLIM metabolic mapping of stem cells and cancer cells in live tissues

Chiara Stringari, Peter Donovan, Enrico Gratton

Proceedings Volume 8226, 82260D (2012) https://doi.org/10.1117/12.909420

KEYWORDS: Fluorescence lifetime imaging, Tissues, Luminescence, Stem cells, Cancer, Collagen, Mode conditioning cables, Green fluorescent protein, In vivo imaging, Image segmentation

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Proceedings Article | 9 February 2012 Paper

In vivo deep tissue fluorescence imaging of the murine small intestine and colon

Viera Crosignani, Alexander Dvornikov, Jose Aguilar, Chiara Stringari, Roberts Edwards, Williams Mantulin, Enrico Gratton

Proceedings Volume 8226, 822609 (2012) https://doi.org/10.1117/12.912841

KEYWORDS: Luminescence, Colon, Intestine, Tissues, Sensors, In vivo imaging, Deep tissue imaging, Stem cells, Microscopes, Imaging systems

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SPIE Journal Paper | 1 November 2011 Open Access

Impact of contralateral and ipsilateral reference tissue selection on self-referencing differential spectroscopy for breast cancer detection

Anais Leproux, Albert Cerussi, Vaya Tanamai, Amanda Durkin, Montana Compton, Bruce Tromberg, Enrico Gratton

JBO, Vol. 16, Issue 11, 116019, (November 2011) https://doi.org/10.1117/12.10.1117/1.3652711

KEYWORDS: Breast, Tissues, Tumors, Tissue optics, Absorption, Spectroscopy, Breast cancer, Cancer, Chromophores, Scattering

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SPIE Journal Paper | 1 September 2011 Open Access

Breast cancer spatial heterogeneity in near-infrared spectra and the prediction of neoadjuvant chemotherapy response

Ylenia Santoro, Bruce Tromberg, Enrico Gratton, Anais Leproux, Albert Cerussi

JBO, Vol. 16, Issue 09, 097007, (September 2011) https://doi.org/10.1117/12.10.1117/1.3638135

KEYWORDS: Tumors, Absorption, Breast cancer, Tissues, Near infrared, Cancer, Visualization, Luminescence, Breast, Scattering

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SPIE Journal Paper | 1 August 2011 Open Access

Correlation of functional and resting state connectivity of cerebral oxy-, deoxy-, and total hemoglobin concentration changes measured by near-infrared spectrophotometry

Ursula Wolf, Vladislav Toronov, Jee Hyun Choi, Rajarsi Gupta, Antonios Michalos, Enrico Gratton, Martin Wolf

JBO, Vol. 16, Issue 08, 087013, (August 2011) https://doi.org/10.1117/12.10.1117/1.3615249

KEYWORDS: Brain, Sensors, Correlation function, Spectrophotometry, Near infrared spectroscopy, Hemodynamics, Information security, Magnetic resonance imaging, Head, Functional magnetic resonance imaging

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SPIE Journal Paper | 1 March 2010 Open Access

Scanning laser image correlation for measurement of flow

Molly Rossow, William Mantulin, Enrico Gratton

JBO, Vol. 15, Issue 02, 026003, (March 2010) https://doi.org/10.1117/12.10.1117/1.3365946

KEYWORDS: Particles, Microfluidics, Velocity measurements, Blood vessels, Speckle, Blood circulation, Microscopes, Blood, Diffusion, Laser scanners

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SPIE Journal Paper | 1 March 2009 Open Access

Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels

Molly Rossow, William Mantulin, Enrico Gratton

JBO, Vol. 14, Issue 02, 024014, (March 2009) https://doi.org/10.1117/12.10.1117/1.3088203

KEYWORDS: Blood vessels, Blood circulation, Particles, Imaging spectroscopy, Speckle, Blood, Spectroscopy, Doppler effect, Velocity measurements, Microfluidics

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Proceedings Article | 13 February 2009 Open Access

Multicolor fluctuation spectroscopy in cells

Michelle Digman, Enrico Gratton

Proceedings Volume 7183, 718303 (2009) https://doi.org/10.1117/12.814875

KEYWORDS: Fluorescence correlation spectroscopy, Diffusion, Proteins, Molecules, Particles, Microscopes, Luminescence, Spectroscopy, Data analysis, Molecular spectroscopy

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SPIE Journal Paper | 1 May 2008 Open Access

Fluorescence correlation spectroscopy and photon counting histogram on membrane proteins: functional dynamics of the glycosylphosphatidylinositol-anchored urokinase plasminogen activator receptor

Gabriele Malengo, Annapaola Andolfo, Nicolai Sidenius, Enrico Gratton, Moreno Zamai, Valeria Caiolfa

JBO, Vol. 13, Issue 03, 031215, (May 2008) https://doi.org/10.1117/12.10.1117/1.2940570

KEYWORDS: Proteins, Diffusion, Fluorescence correlation spectroscopy, Receptors, Photon counting, Luminescence, Molecules, Biological research, Molecular spectroscopy, Statistical analysis

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SPIE Journal Paper | 1 March 2007 Open Access

Intrinsic tumor biomarkers revealed by novel double-differential spectroscopic analysis of near-infrared spectra

Shwayta Kukreti, Albert Cerussi, Bruce Tromberg, Enrico Gratton

JBO, Vol. 12, Issue 02, 020509, (March 2007) https://doi.org/10.1117/12.10.1117/1.2709701

KEYWORDS: Tissues, Tumors, Absorption, Breast, Near infrared, Near infrared spectroscopy, Spectroscopy, Cancer, Tissue optics, Biological research

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SPIE Journal Paper | 1 November 2006 Open Access

Effects of vasodilation on intrinsic optical signals in the mammalian brain: a phantom study

Kandice Tanner, Erin Beitel, Enrico D'Amico, William Mantulin, Enrico Gratton

JBO, Vol. 11, Issue 06, 064020, (November 2006) https://doi.org/10.1117/12.10.1117/1.2398920

KEYWORDS: Scattering, Absorption, Opacity, Brain, Tissue optics, Absorbance, Chromophores, Tissues, Intrinsic optical signal, Blood vessels

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SPIE Journal Paper | 1 January 2006 Open Access

Modulation of an optical needle's reflectivity alters the average photon path through scattering media

Paul Simonson, Enrico D'Amico, Enrico Gratton

JBO, Vol. 11, Issue 01, 014023, (January 2006) https://doi.org/10.1117/12.10.1117/1.2168167

KEYWORDS: Sensors, Reflectivity, Photon transport, Monte Carlo methods, Tissue optics, Diffusion, Modulation, Biomedical optics, Scattering, Target detection

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SPIE Journal Paper | 1 November 2005 Open Access

Spectrally resolved neurophotonics: a case report of hemodynamics and vascular components in the mammalian brain

Kandice Tanner, Enrico D'Amico, Amy Kaczmarowski, Shwayta Kukreti, Joe Malpeli, William Mantulin, Enrico Gratton

JBO, Vol. 10, Issue 06, 064009, (November 2005) https://doi.org/10.1117/12.10.1117/1.2137291

KEYWORDS: Scattering, Tissues, Visualization, Brain, Tissue optics, Hemodynamics, Visual cortex, Light scattering, Sensors, Spectroscopy

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Proceedings Article | 25 April 2005 Paper

Development of the scanning system to detect the concentration of oxy- and deoxy-hemoglobin by tracking the head

Woo Seok Ko, Naser Darwish, Enrico Gratton, Soo Hyun Kim

Proceedings Volume 5686, (2005) https://doi.org/10.1117/12.590755

KEYWORDS: Head, Near infrared spectroscopy, Diffusion, Sensors, Tissue optics, Scanners, Absorption, Scattering, Light scattering, Tissues

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SPIE Journal Paper | 1 January 2005 Open Access

Measurement of brain activity by near-infrared light

Enrico Gratton, Vladislav Toronov, Ursula Wolf, Martin Wolf, Andrew Webb

JBO, Vol. 10, Issue 01, 011008, (January 2005) https://doi.org/10.1117/12.10.1117/1.1854673

KEYWORDS: Brain, Tissues, Functional magnetic resonance imaging, Hemodynamics, Sensors, Signal detection, Near infrared spectroscopy, Tissue optics, Light, Scattering

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SPIE Journal Paper | 1 November 2004 Open Access

Mitigating thermal mechanical damage potential during two-photon dermal imaging

Barry Masters, Peter So, Christof Buehler, Nicholas Barry, Jason Sutin, William Mantulin, Enrico Gratton

JBO, Vol. 9, Issue 06, (November 2004) https://doi.org/10.1117/12.10.1117/1.1806135

KEYWORDS: Pulsed laser operation, Skin, Two photon imaging, Absorption, Laser energy, Cavitation, Luminescence, Laser damage threshold, In vivo imaging, Infrared radiation

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Proceedings Article | 8 September 2004 Paper

Fluorescence lifetime to image epidermal ionic concentrations

Martin Behne, Nicholas Barry, Ingrid Moll, Enrico Gratton, Theodora Mauro

Proceedings Volume 5463, (2004) https://doi.org/10.1117/12.545928

KEYWORDS: Fluorescence lifetime imaging, Luminescence, Skin, Calcium, Visualization, Natural surfaces, Ions, Microscopy, Tissues, Interfaces

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Proceedings Article | 20 August 2004 Paper

Optimization of the phase and modulation depth signal-to-noise ratio for near-infrared spectroscopy of the biological tissue

Vladislav Toronov, Enrico D'Amico, Dennis Hueber, Enrico Gratton, Beniamino Barbieri, Andrew Webb

Proceedings Volume 5474, (2004) https://doi.org/10.1117/12.578960

KEYWORDS: Signal to noise ratio, Modulation, Phase shift keying, Brain, Interference (communication), Imaging spectroscopy, Near infrared spectroscopy, Light sources, Sensors, Tissue optics

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Proceedings Article | 13 July 2004 Paper

Optimization of the frequency-domain instrument for the near-infrared spectro-imaging of the human brain

Vladislav Toronov, Enrico Di Amico, Dennis Hueber, Enrico Gratton, Andrew Webb, Beniamino Barbieri

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.530254

KEYWORDS: Signal to noise ratio, Modulation, Phase shift keying, Brain, Head, Monte Carlo methods, Interference (communication), Imaging spectroscopy, Pulsed laser operation, Scattering

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Proceedings Article | 28 May 2004 Paper

Study of complex hemodynamic fluctuations in the human brain by simultaneous near-infrared spectro-imaging and functional magnetic resonance imaging

Vladislav Toronov, Maria-Angela Franceschini, Sergio Fantini, Andrew Webb, Enrico Gratton

Proceedings Volume 5330, (2004) https://doi.org/10.1117/12.532950

KEYWORDS: Hemodynamics, Brain, Functional magnetic resonance imaging, Near infrared spectroscopy, Neuroimaging, Brain mapping, Tissues, Statistical analysis, Signal detection, Sensors

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Proceedings Article | 28 May 2004 Paper

Spatio-temporal analysis of the cerebral spontaneous oscillation

Jee Choi, Martin Wolf, Vladislav Toronov, Antonios Michalos, Enrico Gratton

Proceedings Volume 5330, (2004) https://doi.org/10.1117/12.548202

KEYWORDS: Near infrared spectroscopy, Fractal analysis, Brain, Pattern recognition, Skin, Tissue optics, Modulation, Protactinium, Hemodynamics, Arteries

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SPIE Journal Paper | 1 January 2004 Open Access

Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach

Jee Choi, Martin Wolf, Vladislav Toronov, Ursula Wolf, Chiara Polzonetti, Dennis Hueber, Larisa Safonova, Rajarsi Gupta, Antonios Michalos, William Mantulin, Enrico Gratton

JBO, Vol. 9, Issue 01, (January 2004) https://doi.org/10.1117/12.10.1117/1.1628242

KEYWORDS: Brain, Optical properties, Oxygen, Sensors, Head, Absorption, Tissue optics, Scattering, Near infrared spectroscopy, Skull

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Proceedings Article | 13 October 2003 Paper

Study of the FMRI blood oxygen level dependent effect by near-infrared spectroscopy

Vladislav Toronov, Andrew Webb, Scott Walker, Rajarsi Gupta, Jee Choi, Enrico Gratton, Dennis Hueber

Proceedings Volume 5068, (2003) https://doi.org/10.1117/12.518770

KEYWORDS: Functional magnetic resonance imaging, Near infrared spectroscopy, Blood, Hemodynamics, Tissue optics, Optical sensors, Calibration, Blood oxygen saturation, Data modeling, Optical properties

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SPIE Journal Paper | 1 July 2003 Open Access

Fluorescence lifetime imaging for the two-photon microscope: time-domain and frequency-domain methods

Enrico Gratton, Sophie Breusegem, Jason Sutin, Qiaoaio Ruan, Nicholas Barry

JBO, Vol. 8, Issue 03, (July 2003) https://doi.org/10.1117/12.10.1117/1.1586704

KEYWORDS: Microscopes, Modulation, Luminescence, Signal to noise ratio, Phase shift keying, Sensors, Analog electronics, Electronics, Molecules, Data acquisition

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Proceedings Article | 16 July 2002 Paper

Functional cerebral activation detected by frequency-domain near-infrared spectroscopy

Vladislav Toronov, Andrew Webb, Jee Choi, Martin Wolf, Larisa Safonova, Ursula Wolf, Enrico Gratton

Proceedings Volume 4707, (2002) https://doi.org/10.1117/12.475639

KEYWORDS: Near infrared spectroscopy, Hemodynamics, Functional magnetic resonance imaging, Brain, Sensors, Tissues, Absorption, Optical sensors, Modulation, Signal detection

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Proceedings Article | 5 June 2002 Paper

Extraction of fast neuronal changes from multichannel functional near-infrared spectroscopy signals using independent component analysis

Geert Morren, Martin Wolf, Philippe Lemmerling, Ursula Wolf, Jee Choi, Enrico Gratton, Lieven De Lathauwer, Sabine Van Huffel

Proceedings Volume 4623, (2002) https://doi.org/10.1117/12.469474

KEYWORDS: Signal detection, Electronic filtering, Near infrared spectroscopy, Independent component analysis, Heart, Time-frequency analysis, Sensors, Digital filtering, Optical filters, Linear filtering

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Proceedings Article | 1 April 2002 Paper

Applications of ultrafast lasers to two-photon fluorescence and lifetime imaging

Nicholas Barry, Kerry Hanson, Enrico Gratton, Robert Clegg, Martin Behne, Thea Mauro

Proceedings Volume 4633, (2002) https://doi.org/10.1117/12.461387

KEYWORDS: Luminescence, Modulation, Skin, Microscopes, Ultrafast lasers, Pulsed laser operation, Signal detection, Picosecond phenomena, Calibration, Femtosecond phenomena

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Proceedings Article | 29 June 2001 Paper

In-vitro correlation between reduced scattering coefficient and hemoglobin concentration of human blood determined by near-infrared spectroscopy

Lelia Paunescu, Antonios Michalos, Jee Choi, Ursula Wolf, Martin Wolf, Enrico Gratton

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434505

KEYWORDS: Glucose, Blood, Scattering, Near infrared, Absorption, Near infrared spectroscopy, Spectroscopy, Light scattering, In vitro testing, Data acquisition

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Proceedings Article | 29 June 2001 Paper

Simultaneous functional magnetic resonance and near-infrared imaging of adult human brain

Vladislav Toronov, Andrew Webb, Jee Choi, Martin Wolf, Enrico Gratton, Dennis Hueber

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434517

KEYWORDS: Near infrared spectroscopy, Functional magnetic resonance imaging, Tissue optics, Signal detection, Magnetic resonance imaging, Brain, Hemodynamics, Neuroimaging, Magnetism, Skull

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Proceedings Article | 28 June 2001 Paper

Simultaneous assessment of human brain functional hemodynamics by magnetic resonance and near-infrared imaging

Vladislav Toronov, Andrew Webb, Jee Choi, Martin Wolf, Enrico Gratton

Proceedings Volume 4320, (2001) https://doi.org/10.1117/12.430911

KEYWORDS: Functional magnetic resonance imaging, Tissues, Brain, Tissue optics, Hemodynamics, Near infrared, Magnetic resonance imaging, Neuroimaging, Absorption, Near infrared spectroscopy

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Proceedings Article | 24 April 2001 Paper

3D particle tracking on the two-photon microscope

Timothy Ragan, Peter So, Hyuk-Sang Kwon, Enrico Gratton

Proceedings Volume 4262, (2001) https://doi.org/10.1117/12.424560

KEYWORDS: Particles, Diffusion, Microscopes, Optical spheres, Point spread functions, Motion models, 3D modeling, Systems modeling, Microscopy, Objectives

SPIE Journal Paper | 1 July 2000 Open Access

Blood flow and oxygen consumption with near-infrared spectroscopy and venous occlusion: spatial maps and the effect of time and pressure of inflation

Claudia Casavola, Lelia Paunescu, Sergio Fantini, Enrico Gratton

JBO, Vol. 5, Issue 03, (July 2000) https://doi.org/10.1117/12.10.1117/1.429995

KEYWORDS: Oxygen, Blood circulation, Mercury, Tissues, Near infrared spectroscopy, Absorption, Tissue optics, Scattering, Sensors, Blood

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Proceedings Article | 27 April 2000 Paper

Magnetic tweezers microscope for cellular manipulation

Chen-Yuan Dong, Hayden Huang, Jason Sutin, Hyuk-Sang Kwon, George Cragg, R. Gilbert, Richard Lee, Enrico Gratton, Roger Kamm, Douglas Lauffenburger, Peter So

Proceedings Volume 3921, (2000) https://doi.org/10.1117/12.384210

KEYWORDS: Magnetism, Particles, Microscopes, Optical spheres, Calibration, Finite element methods, Magnetic tracking, Data acquisition, Iron, Image resolution

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Proceedings Article | 6 April 2000 Paper

Temporal analysis of fluctuations in cerebral hemodynamics revealed by near-infrared spectroscopy

Vlad Toronov, Sergio Fantini, Maria-Angela Franceschini, Mattia Filiaci, Martin Wolf, Enrico Gratton

Proceedings Volume 4001, (2000) https://doi.org/10.1117/12.381494

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Brain, Tissue optics, Electroluminescence, Sensors, Spectroscopy, Neuroimaging, Human subjects, Coherence (optics)

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Proceedings Article | 15 July 1999 Paper

Real-time optical imaging and spectroscopy of brain ischemia and hemorrhage

Miljan Stankovic, Dennis Hueber, Dev Maulik, Phillip Stubblefield, Warren Rosenfeld, Enrico Gratton, Maria-Angela Franceschini, Sergio Fantini

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356808

KEYWORDS: Brain, Blood, Absorption, Spectroscopy, Ischemia, Neuroimaging, Imaging spectroscopy, Optical imaging, Optical spectroscopy, Tissue optics

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Proceedings Article | 15 July 1999 Paper

Calf muscle blood flow and oxygen consumption measured with near-infrared spectroscopy during venous occlusion

Lelia Paunescu, Claudia Casavola, Maria-Angela Franceschini, Sergio Fantini, Lew Winter, Jin Kim, Debra Wood, Enrico Gratton

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356790

KEYWORDS: Blood circulation, Oxygen, Near infrared, Tissues, Near infrared spectroscopy, Vascular diseases, Tissue optics, Control systems, Blood, Doppler effect

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Proceedings Article | 15 July 1999 Paper

Photon-density wave fluctuation correlation spectroscopy: study of coherence in the brain and muscles

Vlad Toronov, Mattia Filiaci, Maria-Angela Franceschini, Sergio Fantini, Enrico Gratton

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356814

KEYWORDS: Head, Tissue optics, Sensors, Brain, Tissues, Near infrared, Spectroscopy, Data modeling, Light, Coherence (optics)

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Proceedings Article | 15 July 1999 Paper

Near-infrared spectroscopy and the tilting table protocol: a novel method to study the blood flow and the oxygen consumption in tissues

Claudia Casavola, Lelia Paunescu, Maria-Angela Franceschini, Sergio Fantini, Lew Winter, Jin Kim, Debra Wood, Enrico Gratton

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356789

KEYWORDS: Oxygen, Blood circulation, Tissues, Near infrared, Spectroscopy, Optical fibers, Blood, Near infrared spectroscopy, Tissue optics, Vascular diseases

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Proceedings Article | 15 July 1999 Paper

Near-infrared absorption and scattering spectra of tissues in vivo

Maria-Angela Franceschini, Enrico Gratton, Dennis Hueber, Sergio Fantini

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356854

KEYWORDS: Tissues, Absorption, Scattering, Tissue optics, Ischemia, Optical fibers, Spectroscopy, In vivo imaging, Optical properties, Skin

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Proceedings Article | 2 July 1999 Paper

Fluorescence lifetime spectroscopy in multiple-scattering environments: an application to biotechnology

Albert Cerussi, Enrico Gratton, Sergio Fantini

Proceedings Volume 3600, (1999) https://doi.org/10.1117/12.351028

KEYWORDS: Luminescence, Fluorescence spectroscopy, Spectroscopy, Tissues, Absorption, Scattering, Diffusion, Optical properties, Sensors, Quantum efficiency

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Proceedings Article | 21 April 1999 Paper

Frequency-domain pump-probe microscopic imaging using intensity-modulated laser diodes

Christof Buehler, Chen-Yuan Dong, Peter So, Todd French, Enrico Gratton

Proceedings Volume 3603, (1999) https://doi.org/10.1117/12.346749

KEYWORDS: Semiconductor lasers, Luminescence, Modulation, Microscopy, Laser beam diagnostics, Pulsed laser operation, Signal detection, Spatial resolution, Optical spheres, Microscopes

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Proceedings Article | 4 March 1999 Paper

Exploring tissue dynamics by photon-density-wave fluctuation correlation spectroscopy

Vlad Toronov, Mattia Filiaci, Maria-Angela Franceschini, Sergio Fantini, Enrico Gratton

Proceedings Volume 3726, (1999) https://doi.org/10.1117/12.341442

KEYWORDS: Particles, Tissue optics, Spectroscopy, In vivo imaging, Spectroscopes, Modulation, Tissues, Optical properties, Phase shift keying, Light scattering

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Proceedings Article | 29 April 1998 Paper

Two-photon fluorescence and confocal reflected light imaging of thick tissue structures

Ki Kim, Peter So, Irene Kochevar, Barry Masters, Enrico Gratton

Proceedings Volume 3260, (1998) https://doi.org/10.1117/12.307081

KEYWORDS: Confocal microscopy, Luminescence, Tissues, Tissue optics, Microscopes, Skin, Photons, Chromophores, Objectives, Optical spheres

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Proceedings Article | 1 January 1998 Paper

Difference in leg muscle oxygenation during treadmill exercise by a new near-infrared frequency-domain oximeter

Valentina Quaresima, Maria-Angela Franceschini, Sergio Fantini, Enrico Gratton, Marco Ferrari

Proceedings Volume 3194, (1998) https://doi.org/10.1117/12.301042

KEYWORDS: Oximeters, Near infrared, Thermal modeling

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Proceedings Article | 1 January 1998 Paper

Quantitative near-infrared spectroscopy on patients with peripheral vascular disease

Maria-Angela Franceschini, Sergio Fantini, Renato Palumbo, Leonella Pasqualini, Gaetano Vaudo, Edoardo Franceschini, Enrico Gratton, Barbara Palumbo, Salvatore Innocente, Elmo Mannarino

Proceedings Volume 3194, (1998) https://doi.org/10.1117/12.301041

KEYWORDS: Near infrared spectroscopy, Vascular diseases, Control systems, Laser tissue interaction, Oximeters, Modulation, Semiconductor lasers, Tissue optics

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Proceedings Article | 18 August 1997 Paper

Effect of spatially distributed light sources on the frequency-domain solution to the diffusion equation

Sergio Fantini, Maria-Angela Franceschini, Enrico Gratton

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280285

KEYWORDS: Diffusion, Light sources, Optical fibers, Optical testing, Scattering media, Absorption, Scattering, Photons, Calibration

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Proceedings Article | 18 August 1997 Paper

Chromophore detection by fluorescence spectroscopy in tissue-like phantoms

Albert Cerussi, Sergio Fantini, John Maier, William Mantulin, Enrico Gratton

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280240

KEYWORDS: Luminescence, Tissues, Fluorescence spectroscopy, Absorption, Rhodamine, Scattering, Tissue optics, Spectroscopy, Diffusion, Interference filters

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Proceedings Article | 18 August 1997 Paper

Effect of index of refraction mismatch on the recovery of optical properties of cylindrical inhomogeneities in an infinite turbid medium

Scott Walker, Sergio Fantini, Enrico Gratton

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280248

KEYWORDS: Refraction, Scattering, Reflection, Absorption, Diffusion, Optical properties, Sensors, Data modeling, Phase measurement, Tissues

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Proceedings Article | 18 August 1997 Paper

Experimental recovery of absorption, scattering, and fluorescence parameters in highly scattering media from a single frequency measurement

John Maier, Albert Cerussi, Sergio Fantini, Enrico Gratton

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280223

KEYWORDS: Scattering, Luminescence, Absorption, Tissues, Quantum efficiency, Light scattering, Sensors, Spectroscopy, Signal detection, Physics

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Proceedings Article | 18 August 1997 Paper

Optical study of the skeletal muscle during exercise with a second-generation frequency-domain tissue oximeter

Maria-Angela Franceschini, Don Wallace, Beniamino Barbieri, Sergio Fantini, William Mantulin, Simone Pratesi, Gian Paolo Donzelli, Enrico Gratton

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280229

KEYWORDS: Tissue optics, Prototyping, Oximeters, Light emitting diodes, Semiconductor lasers, Light sources, In vivo imaging, Tissues, Electronics, Optical fibers

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Proceedings Article | 23 May 1997 Paper

Two-photon single particle tracking in 3D

Peter So, Timothy Ragan, Enrico Gratton, Jenny Carerro, Edward Voss

Proceedings Volume 2983, (1997) https://doi.org/10.1117/12.274323

KEYWORDS: Particles, Optical spheres, Diffusion, Latex, Luminescence, Photons, Proteins, Confocal microscopy, Microscopy, Receptors

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Proceedings Article | 23 May 1997 Open Access

Cell damage in UVA and cw/femtosecond NIR microscopes

Karsten Koenig, Hong Liang, Sol Kimel, Lars Svaasand, Bruce Tromberg, Tatiana Krasieva, Michael Berns, Karl-Juergen Halbhuber, Peter So, William Mantulin, Enrico Gratton

Proceedings Volume 2983, (1997) https://doi.org/10.1117/12.274337

KEYWORDS: Near infrared, Femtosecond phenomena, Microscopes, Continuous wave operation, Luminescence, Objectives, Absorption, Optical tweezers, Microscopy, Cell death

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SPIE Journal Paper | 2 April 1997 Open Access

Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: analysis of the effect of water absorption

Maria-Angela Franceschini, Sergio Fantini, Albert Cerussi, Beniamino Barbieri, Britton Chance, Enrico Gratton

JBO, Vol. 2, Issue 02, (April 1997) https://doi.org/10.1117/12.10.1117/12.262145

KEYWORDS: Absorption, Tissue optics, Oxygen, Tissues, Spectroscopy, Blood, Oximeters, Nitrogen, Near infrared, Mercury

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Proceedings Article | 6 December 1996 Paper

Cell damage in two-photon microscopes

Karsten Koenig, Peter So, William Mantulin, Enrico Gratton

Proceedings Volume 2926, (1996) https://doi.org/10.1117/12.260794

KEYWORDS: Near infrared, Femtosecond phenomena, Luminescence, Microscopes, Photons, Objectives, Microscopy, Nondestructive evaluation, Plasma, 3D image processing

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Proceedings Article | 10 May 1996 Paper

Fluorescence lifetime microscopy: a stimulated emission approach

Enrico Gratton, Chen Dong, Peter So

Proceedings Volume 2678, (1996) https://doi.org/10.1117/12.239514

KEYWORDS: Microscopy, Luminescence, Microscopes, Laser beam diagnostics, Confocal microscopy, Spectroscopy, Modulation, Spatial resolution, Photons, Signal detection

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Proceedings Article | 15 January 1996 Open Access

Two-photon excited cellular autofluorescence induced by cw and femtosecond NIR microradiation

Karsten Koenig, Peter So, William Mantulin, Enrico Gratton, Tatiana Krasieva, Michael Berns, Bruce Tromberg

Proceedings Volume 2628, (1996) https://doi.org/10.1117/12.229988

KEYWORDS: Luminescence, Near infrared, Continuous wave operation, Laser scanners, Absorption, Femtosecond phenomena, Microscopes, Optical tweezers, Auto-fluorescence imaging

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Proceedings Article | 30 May 1995 Paper

Cerebral and muscle oxygen saturation measurement by a frequency-domain near-infrared spectroscopic technique

Marco Ferrari, Roberto De Blasi, Sergio Fantini, Maria-Angela Franceschini, Beniamino Barbieri, Valentina Quaresima, Enrico Gratton

Proceedings Volume 2389, (1995) https://doi.org/10.1117/12.209950

KEYWORDS: Absorption, Scattering, Near infrared spectroscopy, Oxygen, Ischemia, Brain, Spectroscopes, Blood, Light emitting diodes, Spectroscopy

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Proceedings Article | 30 May 1995 Paper

Multichannel optical instrument for near-infrared imaging of tissue

Maria-Angela Franceschini, Sergio Fantini, Scott Walker, John Maier, William Mantulin, Enrico Gratton

Proceedings Volume 2389, (1995) https://doi.org/10.1117/12.209975

KEYWORDS: Scattering, Optical properties, Absorption, Sensors, Tissue optics, Modulation, Optical spheres, Light sources, Glasses, Light scattering

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Proceedings Article | 30 May 1995 Paper

Photon path distributions in turbid media: applications for imaging

Sergio Fantini, Maria-Angela Franceschini, Scott Walker, John Maier, Enrico Gratton

Proceedings Volume 2389, (1995) https://doi.org/10.1117/12.209984

KEYWORDS: Sensors, Scattering, Absorption, Phase measurement, Optical tomography, Tomography, Light scattering, Light, Tissue optics, Modulation

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Proceedings Article | 30 May 1995 Paper

Back-projection image reconstruction using photon density waves in tissues

Scott Walker, Albert Cerussi, Enrico Gratton

Proceedings Volume 2389, (1995) https://doi.org/10.1117/12.209985

KEYWORDS: Absorption, Scattering, Optical spheres, Sensors, Tissues, Glasses, Light scattering, Computed tomography, Tomography, X-rays

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Proceedings Article | 1 May 1995 Paper

Tissue optical parameter map generated with frequency-domain spectroscopy

William Mantulin, Sergio Fantini, Maria Angela Franceschini, Scott Walker, John Maier, Enrico Gratton

Proceedings Volume 2396, (1995) https://doi.org/10.1117/12.208420

KEYWORDS: Tissue optics, Scattering, Geometrical optics, Light scattering, Absorption, Sensors, Modulation, Image processing, Optical imaging, Spectroscopy

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Proceedings Article | 12 April 1995 Paper

In vivo study of human tissues with a portable near-IR tissue spectrometer

John Maier, Beniamino Barbieri, Arun Chervu, Indira Chervu, Sergio Fantini, Maria-Angela Franceschini, Moshe Levi, William Mantulin, Adam Rosenberg, Scott Walker, Enrico Gratton

Proceedings Volume 2387, (1995) https://doi.org/10.1117/12.206828

KEYWORDS: Tissues, Blood, Sensors, Absorption, Spectroscopy, Scattering, Ischemia, Vascular diseases, In vivo imaging, Head

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Proceedings Article | 31 January 1995 Paper

Frequency-domain multisource optical spectrometer and oximeter

Sergio Fantini, Maria-Angela Franceschini, John Maier, Scott Walker, Enrico Gratton

Proceedings Volume 2326, (1995) https://doi.org/10.1117/12.200811

KEYWORDS: Light emitting diodes, Tissue optics, Light sources, Sensors, Signal detection, Spectroscopy, Absorption, Scattering, Tissues, Light scattering

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SPIE Journal Paper | 1 January 1995

Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry

Sergio Fantini, Maria-Angela Franceschini, John Maier, Scott Walker, Beniamino Barbieri, Enrico Gratton

OE, Vol. 34, Issue 01, (January 1995) https://doi.org/10.1117/12.10.1117/12.183988

KEYWORDS: Light emitting diodes, Tissue optics, Absorption, Sensors, Light sources, Tissues, Scattering, Spectroscopy, Modulation, Calibration

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Proceedings Article | 17 August 1994 Paper

Effect of disordered hemes and dimerization in isolated a-subunits of hemoglobin detected by time-resolved fluorescence spectroscopy in the picosecond range

Zygmunt Gryczynski, Clara Fronticelli, Enrico Gratton, Jacek Lubkowski, Enrico Bucci

Proceedings Volume 2137, (1994) https://doi.org/10.1117/12.182718

KEYWORDS: Energy transfer, Absorption, Proteins, Picosecond phenomena, Near ultraviolet, Time resolved spectroscopy, Dichroic materials, Optical filters, Oscillators, Lanthanum

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Proceedings Article | 17 August 1994 Paper

Frequency domain time-resolved microscope using a fast-scan CCD camera

Peter So, Todd French, Enrico Gratton

Proceedings Volume 2137, (1994) https://doi.org/10.1117/12.182713

KEYWORDS: Modulation, Luminescence, Microscopes, Phase shift keying, Microchannel plates, Optical spheres, CCD cameras, Heterodyning, Cameras, Phase shifts

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Proceedings Article | 28 July 1994 Paper

Absolute measurement of absorption and scattering coefficients spectra of a multiply scattering medium

Sergio Fantini, Maria-Angela Franceschini, Joshua Fishkin, Enrico Gratton

Proceedings Volume 2131, (1994) https://doi.org/10.1117/12.180732

KEYWORDS: Scattering, Light emitting diodes, Absorption, Tissues, Light scattering, Modulation, Diffusion, Light sources, Spectrophotometry, Signal detection

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Proceedings Article | 28 June 1994 Paper

Absorption spectra of a chromophore in highly scattering media

Sergio Fantini, Maria-Angela Franceschini, Joshua Fishkin, William Mantulin, Enrico Gratton

Proceedings Volume 2100, (1994) https://doi.org/10.1117/12.178989

KEYWORDS: Scattering, Absorption, Light scattering, Modulation, Tissue optics, Diffusion, Chromophores, Tissues, Diodes, Optical properties

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Proceedings Article | 28 June 1994 Paper

Spectroscopic innovations at the laboratory for fluorescence dynamics

William Mantulin, Enrico Gratton

Proceedings Volume 2100, (1994) https://doi.org/10.1117/12.178995

KEYWORDS: Luminescence, Sensors, Microchannel plates, Modulation, Signal processing, Fluorescence spectroscopy, Signal detection, Biological research, Heterodyning, Phase shift keying

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Proceedings Article | 19 May 1994 Paper

LEDs in frequency domain spectroscopy of tissues

Maria-Angela Franceschini, Sergio Fantini, Enrico Gratton

Proceedings Volume 2135, (1994) https://doi.org/10.1117/12.176004

KEYWORDS: Light emitting diodes, Modulation, Spectroscopy, Tissues, Light sources, Scattering, Lamps, In vivo imaging, Absorption, Signal detection

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Proceedings Article | 14 September 1993 Paper

Quantitative diffusive wave spectroscopy in tissues

William Mantulin, Joshua Fishkin, Peter So, Enrico Gratton, John Maier

Proceedings Volume 1888, (1993) https://doi.org/10.1117/12.154661

KEYWORDS: Absorption, Scattering, Modulation, Tissues, Photons, Phase shift keying, Scattering media, Light scattering, Spectroscopy, Diffusion

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Proceedings Article | 14 September 1993 Paper

Frequency-domain methods in optical tomography: detection of localized absorbers and a backscattering reconstruction scheme

John Maier, Enrico Gratton

Proceedings Volume 1888, (1993) https://doi.org/10.1117/12.154663

KEYWORDS: Optical spheres, Sensors, Scattering, Modulation, Phase shift keying, Backscatter, Diffraction, Absorption, Diffusion, Tissues

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Proceedings Article | 5 August 1993 Paper

Frequency-domain measurements of photon migration in highly scattering media

Enrico Gratton

Proceedings Volume 10311, 103110V (1993) https://doi.org/10.1117/12.2283776

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Proceedings Article | 5 August 1993 Paper

Techniques C: frequency domain

E. Gratton

Proceedings Volume 10311, 103110S (1993) https://doi.org/10.1117/12.2283773

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Proceedings Article | 7 July 1993 Paper

Optical imaging in the frequency domain

William Mantulin, Todd French, Enrico Gratton

Proceedings Volume 1892, (1993) https://doi.org/10.1117/12.147495

KEYWORDS: Modulation, Sensors, Phase shift keying, Cameras, Laser systems engineering, Microchannel plates, Phase shifts, Image intensifiers, Imaging systems, Heterodyning

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