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10 November 2016 Separating melanin from hemodynamics in nevi using multimode hyperspectral dermoscopy and spatial frequency domain spectroscopy
Fartash Vasefi, Nicholas MacKinnon, Rolf Saager, Kristen M. Kelly, Tyler Maly, Nicholas Booth, Anthony J. Durkin, Daniel L. Farkas
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Journal of Biomedical Optics, Vol. 21, Issue 11, 114001 (November 2016). https://doi.org/10.1117/1.JBO.21.11.114001
Abstract
Changes in the pattern and distribution of both melanocytes (pigment producing) and vasculature (hemoglobin containing) are important in distinguishing melanocytic proliferations. The ability to accurately measure melanin distribution at different depths and to distinguish it from hemoglobin is clearly important when assessing pigmented lesions (benign versus malignant). We have developed a multimode hyperspectral dermoscope (SkinSpect™) able to more accurately image both melanin and hemoglobin distribution in skin. SkinSpect uses both hyperspectral and polarization-sensitive measurements. SkinSpect’s higher accuracy has been obtained by correcting for the effect of melanin absorption on hemoglobin absorption in measurements of melanocytic nevi. In vivo human skin pigmented nevi (N=20) were evaluated with the SkinSpect, and measured melanin and hemoglobin concentrations were compared with spatial frequency domain spectroscopy (SFDS) measurements. We confirm that both systems show low correlation of hemoglobin concentrations with regions containing different melanin concentrations (R=0.13 for SFDS, R=0.07 for SkinSpect).
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2016/$25.00 © 2016 SPIE
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Fartash Vasefi, Nicholas MacKinnon, Rolf Saager, Kristen M. Kelly, Tyler Maly, Nicholas Booth, Anthony J. Durkin, and Daniel L. Farkas "Separating melanin from hemodynamics in nevi using multimode hyperspectral dermoscopy and spatial frequency domain spectroscopy," Journal of Biomedical Optics 21(11), 114001 (10 November 2016). https://doi.org/10.1117/1.JBO.21.11.114001
Published: 10 November 2016
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KEYWORDS
Skin
Absorption
Hemodynamics
Tissue optics
Ultrasonography
Melanoma
Signal attenuation
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