Tissue deoxygenation kinetics induced by prolonged hypoxic exposure in healthy humans at rest

Thomas Rupp; Thomas Leti; Marc Jubeau; Guillaume Y. Millet; Veronique A. Bricout; Patrick Levy; Bernard Wuyam; Stephane Perrey; Samuel Verges

doi:10.1117/1.JBO.18.9.095002

24 September 2013 Tissue deoxygenation kinetics induced by prolonged hypoxic exposure in healthy humans at rest

Thomas Rupp, Thomas Leti, Marc Jubeau, Guillaume Y. Millet, Veronique A. Bricout, Patrick Levy, Bernard Wuyam, Stephane Perrey, Samuel Verges

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Journal of Biomedical Optics, Vol. 18, Issue 9, 095002 (September 2013). https://doi.org/10.1117/1.JBO.18.9.095002

Abstract

This study aimed to investigate the effects of sustained hypoxic exposure on cerebral and muscle oxygenation and cardiorespiratory function at rest. Eleven healthy subjects inhaled a normobaric hypoxic (FiO ₂ =0.12 ) or normoxic (FiO ₂ =0.21 ) gas mixture for 4 h at rest, on two separated blinded sessions. Arterial oxygen saturation (SpO ₂ ), heart rate variability (HRV), end-tidal CO ₂ (EtCO₂ ), and oxygenation of quadriceps muscle, prefrontal and motor cortices assessed by near-infrared spectroscopy (NIRS) were measured continuously during each session. Acute mountain sickness symptoms were evaluated at the end of each session. During a hypoxic session, SpO ₂ reduction (∼13% ) plateaued after 20 min, while deoxygenation pattern took 30 to 40 min at the cerebral sites to plateau (+5.3±1.6 μMol of deoxygenated-hemoglobin). Deoxygenation was more pronounced in the cerebral cortex compared to the muscle (+2.1±2.3 μMol of deoxygenated-hemoglobin), and NIRS-derived tissue perfusion index showed distinct profiles between the muscle (hypoperfusion) and the brain (hyperperfusion) with prolonged hypoxia. Changes in tissue oxygenation were not associated with cardiorespiratory responses (e.g., HRV, EtCO _{2 [}/sub] ) and altitude sickness symptom appearance during hypoxic sessions. These data demonstrate that sustained hypoxia elicits time delay in changes between arterial and tissue (especially cerebral) oxygenation, as well as a tissue-specific sensitivity.

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Thomas Rupp, Thomas Leti, Marc Jubeau, Guillaume Y. Millet, Veronique A. Bricout, Patrick Levy, Bernard Wuyam, Stephane Perrey, and Samuel Verges "Tissue deoxygenation kinetics induced by prolonged hypoxic exposure in healthy humans at rest," Journal of Biomedical Optics 18(9), 095002 (24 September 2013). https://doi.org/10.1117/1.JBO.18.9.095002

Published: 24 September 2013

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