Feasibility of spatial frequency-domain imaging for monitoring palpable breast lesions

Constance M. Robbins; Guruprasad Raghavan; James F. Antaki; Jana M. Kainerstorfer

doi:10.1117/1.JBO.22.12.121605

22 August 2017 Feasibility of spatial frequency-domain imaging for monitoring palpable breast lesions

Constance M. Robbins, Guruprasad Raghavan, James F. Antaki, Jana M. Kainerstorfer

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Journal of Biomedical Optics, Vol. 22, Issue 12, 121605 (August 2017). https://doi.org/10.1117/1.JBO.22.12.121605

Abstract

In breast cancer diagnosis and therapy monitoring, there is a need for frequent, noninvasive disease progression evaluation. Breast tumors differ from healthy tissue in mechanical stiffness as well as optical properties, which allows optical methods to detect and monitor breast lesions noninvasively. Spatial frequency-domain imaging (SFDI) is a reflectance-based diffuse optical method that can yield two-dimensional images of absolute optical properties of tissue with an inexpensive and portable system, although depth penetration is limited. Since the absorption coefficient of breast tissue is relatively low and the tissue is quite flexible, there is an opportunity for compression of tissue to bring stiff, palpable breast lesions within the detection range of SFDI. Sixteen breast tissue-mimicking phantoms were fabricated containing stiffer, more highly absorbing tumor-mimicking inclusions of varying absorption contrast and depth. These phantoms were imaged with an SFDI system at five levels of compression. An increase in absorption contrast was observed with compression, and reliable detection of each inclusion was achieved when compression was sufficient to bring the inclusion center within ∼12 mm of the phantom surface. At highest compression level, contrasts achieved with this system were comparable to those measured with single source–detector near-infrared spectroscopy.

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Constance M. Robbins, Guruprasad Raghavan, James F. Antaki, and Jana M. Kainerstorfer "Feasibility of spatial frequency-domain imaging for monitoring palpable breast lesions," Journal of Biomedical Optics 22(12), 121605 (22 August 2017). https://doi.org/10.1117/1.JBO.22.12.121605

Received: 31 May 2017; Accepted: 27 July 2017; Published: 22 August 2017

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