Dr. Aguinaldo Segundo Garcez Profile

Dr. Aguinaldo Segundo Garcez

at São Leopoldo Mandic Dental Research Ctr.

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Proceedings Article | 28 February 2020 Paper

Photodynamic therapy: alternative in decontamination of surfaces

A. A. Foggiato, A. S. Garcez, A. Fuziy, D. F. Silva

Proceedings Volume 11223, 112230K (2020) https://doi.org/10.1117/12.2542918

KEYWORDS: Photodynamic therapy, Oxygen, Dentistry, Microorganisms, Picosecond phenomena, Light emitting diodes, Patents, Ultrasonics, Biomedical optics, Tissues

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Photodynamic Therapy (PDT) is an alternative to surfaces decontamination which is based on the interaction between a non-toxic photosensitizer (PS) and a light source suitable for the formation of reactive oxygen species. The objective of this work was to test two new patented devices, the “Photodynamic Inactivation Device” (PID) (MU-BR20.2017.002297- 3) and “Ultrasonic Photodynamic Inactivation Device" (UPID) (MU-BR 20.2018.009356-3), in the photodynamic inactivation (PDI) on contaminated solid surfaces. This device contains low cost light emitting diodes (LEDs) and was built on structures to improve light distribution. This, a low-cost alternative was tested in different microorganisms present on the human microbiota: Staphylococcus aureus, Streptococcus mutans, Escherichia coli and Candida albicans. Results showed that PID caused a significant reduction (p<0.05) of the microbial charge stuck in the orthodontic instruments and the UPID promoted significant reduction (p<0.001) of the microbial in the acrylic plates and titanium disk when compared with the positive control. The new device promoted an effective microbial inhibition on the surfaces tested and, thus, making new studies possible. The perspective is that this new device may be a low-cost and non-toxic alternative to the disinfection of biomedical devices, non-critical instruments and for use in food industry.

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