Dr. Amir Toor Profile

Dr. Amir Toor

at Virginia Commonwealth Univ

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 4 March 2019 Paper

Application of quantitative phase imaging mass accumulation measurements to research and clinical problems in cancer

Graeme Murray, Tia Turner, Tareq Saleh, Mohammad Alzubi, Amir Toor, David Gewirtz, J. Chuck Harrell, Jason Reed

Proceedings Volume 10887, 108871E (2019) https://doi.org/10.1117/12.2514597

KEYWORDS: Tumors, Cancer, Biopsy, Resistance, Clinical research, Interferometry, In vitro testing, Breast cancer, Therapeutics

Read Abstract +

The robustness of Quantitative Phase Imaging (QPI) has enabled QPI to be used in applications to answer both research and clinical questions. QPI requires no labels, is non-destructive, and has nanoscale sensitivity to 3-d morphology. Various applications have included recording cellular force dynamics, identifying parasite-infected red blood cells, detecting cancer prognosis from colon cancer samples, and most recently predicting therapeutic sensitivity from live cell biomass accumulation measurements in patient derived xenograft (PDX) mice. However, challenges remain for clinical adoption, as QPI-based methods must first be proven more effective than current standards of care and patient inconvenience and costs must be minimized. Here we applied basic upgrades to previously described High Speed Live Cell Interferometry (HSLCI) to predict in vivo and in vitro PDX mouse tumor sensitivity to a range of cancer drugs from only Fine Needle Biopsy of the tumor. As demonstrated by our group and many others, the applications of QPI are not limited to the clinical realm. Using HSLCI, we revealed the growth dynamics of senescent and control H460 lung large cell carcinoma cells treated with cancer chemotherapy. The continued improvements in optics and throughput of QPI promise to answer many more clinical and basic science questions.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years