Prof. Anita Mahadevan-Jansen Profile

Prof. Anita Mahadevan-Jansen

Professor of Biomedical Engg at Vanderbilt Univ

SPIE Involvement:

Compensation Committee | Conference Program Committee | Track Chair | Editorial Board Member: Biophotonics Discovery | Author | Editor | Student Chapter Advisor

Area of Expertise:

Optical Spectroscopy , Optical Imaging , Optical Stimulation , Biomedical Optics , Optical Diagnosis , Optical Guidance of Therapy

Websites:

Company Website

Publications (105)

Proceedings Article | 4 October 2024 Presentation + Paper

Presentation + Paper

Deep-learning-based acquisitional denoising for Raman spectroscopy using CNN and transformer

Marilyn Lionts, Ezekiel Haugen, Anita Mahadevan-Jansen, Yuankai Huo

Proceedings Volume 13118, 1311807 (2024) https://doi.org/10.1117/12.3027465

KEYWORDS: Denoising, Transformers, Raman spectroscopy, Data modeling, Signal to noise ratio, Machine learning, Esophagus, Deep learning, Biomedical applications, Tissues

Read Abstract +

Proceedings Article | 13 March 2024 Poster

Poster

Miniaturized handheld laser speckle contrast imaging for evaluating parathyroid glands viability

Han Dong, Parker Willmon, Sean Fitzgerald, Emmanuel Mannoh, Carmen Solórzano, Anita Mahadevan-Jansen

Proceedings Volume PC12818, (2024) https://doi.org/10.1117/12.3011340

KEYWORDS: Laser speckle contrast imaging, Miniaturization, Animals, Biomedical applications, Surgery, Tissues, Tissue optics, Thyroid, Portability, Classification systems

Read Abstract +

Proceedings Article | 13 March 2024 Presentation

Presentation

Assessment of liver steatosis using an ambient light-compatible Raman system: enhancing specificity with supplementary reflectance information

Hao Guo, Ashley Stueck, Jason Doppenberg, Yun Suk Chae, Alexey Tikhomirov, Haishan Zeng, Boris Gala-Lopez, Anita Mahadevan-Jansen, Marten Engelse, Ian P. Alwayn, Andrea Locke, Kevin Hewitt

Proceedings Volume PC12839, PC128390B (2024) https://doi.org/10.1117/12.3009086

KEYWORDS: Raman spectroscopy, Liver, Reflectivity, Data modeling, Vibration, Transplantation, Spectroscopy, Portability, Light sources and illumination, Histopathology

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Proceedings Article | 13 March 2024 Presentation

Presentation

Varying laser pulse widths influence infrared neural stimulation efficacy in vitro

Jacob Hardenburger, Bryan Gamboa, Joel Bixler, Christopher Valdez, Bryan Millis, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 12829, 1282905 (2024) https://doi.org/10.1117/12.3004830

KEYWORDS: In vitro testing, Infrared radiation, Pulsed laser operation, Pulse signals, Neurons, Calcium, Infrared imaging, Optical fibers, Nervous system, Microscopes

Read Abstract +

SPIE Journal Paper | 10 August 2023 Open Access

Open Access

Multiparameter interferometric polarization-enhanced imaging differentiates carcinoma in situ from inflammation of the bladder: an ex vivo study

Shuang Chang, Giovanna A. Giannico, Ezekiel Haugen, Ali Jardaneh, Justin Baba, Anita Mahadevan-Jansen, Sam S. Chang, Audrey K. Bowden

JBO, Vol. 28, Issue 10, 102907, (August 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.10.102907

KEYWORDS: Tissues, Inflammation, Biological samples, Collagen, Second harmonic generation, Tumors, Birefringence, Copper indium disulfide, Bladder, Biomedical optics

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Proceedings Article | 17 March 2023 Presentation

Presentation

Tissue perfusion analysis of parathyroid glands using ICG with probe-based fluorescence detection during neck surgeries

Parker Willmon, Giju Thomas, Colleen Kiernan, Naira Baregamian, Carmen Solórzano, Anita Mahadevan-Jansen

Proceedings Volume 12354, 123540F (2023) https://doi.org/10.1117/12.2650977

KEYWORDS: Tissues, Surgery, Neck, Fluorescence spectroscopy, Luminescence, Mathematical modeling, Tissue optics, Near infrared, Mathematics, Indocyanine green

Read Abstract +

Proceedings Article | 17 March 2023 Presentation

Presentation

Handheld laser speckle contrast imaging for intraoperative detection of parathyroid gland perfusion

Han Dong, Parker Willmon, Pratheepa Rasiah, Graham Throckmorton, Emmanuel Mannoh, Giju Thomas, Anita Mahadevan-Jansen

Proceedings Volume 12354, 123540G (2023) https://doi.org/10.1117/12.2668718

KEYWORDS: Laser speckle contrast imaging, Imaging systems, Cancer detection, Thyroid, Visual inspection, Vascular diseases, Tissues, Surgery, Mouse models, Laser development

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Proceedings Article | 17 March 2023 Presentation

Presentation

Integrated Raman spectroscopy and optical coherence tomography system for characterizing otitis media

Guillermo Monroy, Sean Fitzgerald, Andrea Locke, Jungeun Won, Darold Spillman, Alexander Ho, Farzana Zaki, Honggu Choi, Eric Chaney, Jay Werkhaven, Kevin Mason, Anita Mahadevan-Jansen, Stephen Boppart

Proceedings Volume 12354, 1235404 (2023) https://doi.org/10.1117/12.2648504

KEYWORDS: Optical coherence tomography, Ear, Raman spectroscopy, Remote sensing, Visualization, Prototyping, In vitro testing, Human subjects, Diagnostics, Bone

Read Abstract +

Proceedings Article | 17 March 2023 Presentation

Presentation

Developing a molecular understanding for using Raman spectroscopy to measure tissue hydration

Trevor Voss, Anita Mahadevan-Jansen

Proceedings Volume PC12363, PC1236306 (2023) https://doi.org/10.1117/12.2650898

KEYWORDS: Raman spectroscopy, Molecular spectroscopy, Tissue optics, Skin, Natural surfaces, Urea, Sodium, Ions, Environmental sensing, Computer simulations

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Proceedings Article | 17 March 2023 Presentation

Presentation

Tackling women's health problems with optical imaging and spectroscopy

Christine O'Brien, Francesca Bonetta-Misetli, Kevin Bishop, Leonid Shmuylovich, Laura Masson, J.M. Newton, Jeff Reese, Anita Mahadevan-Jansen, Samuel Achilefu

Proceedings Volume PC12363, PC123630S (2023) https://doi.org/10.1117/12.2660425

KEYWORDS: Spectroscopy, Optical spectroscopy imaging, Optical spectroscopy, Optical imaging, Imaging spectroscopy, Medicine, Medical research, Therapeutics, Surgery, Point-of-care devices

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Proceedings Article | 15 March 2023 Presentation + Paper

Presentation + Paper

Proceduralist criteria for evaluating interface utility of novel imaging modalities in early phase clinical trials: evaluating the need for standardized criteria

Eric Henderson, Jonathan Elliott, Shudong Jiang, I. Leah Gitajn, John Lee, Summer Gibbs, Michael Bouvet, Anita Mahadevan-Jansen, Michael Daly, Samuel Streeter, Keith Paulsen, Brian Pogue, Kimberley Samkoe, Sunil Singhal

Proceedings Volume 12361, 123610F (2023) https://doi.org/10.1117/12.2650756

KEYWORDS: Surgery, Tissues, Target recognition, Standards development, Visualization, Medical imaging, Imaging technologies, Clinical trials, Interfaces, Fluorophores

Read Abstract +

Proceedings Article | 6 March 2023 Presentation

Presentation

In vivo Raman spectroscopy for sensing esophageal biomolecular changes in children with eosinophilic esophagitis

Ezekiel Haugen, Andrea Locke, Hernan Correa, Regina Tyree, Girish Hiremath, Justin Baba, Anita Mahadevan-Jansen

Proceedings Volume PC12373, PC123730F (2023) https://doi.org/10.1117/12.2650697

KEYWORDS: Raman spectroscopy, In vivo imaging, Biosensing, Remote sensing, Tissues, Scattering, Raman scattering, Proteins, Point-of-care devices, Molecular spectroscopy

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Proceedings Article | 12 May 2022 Presentation

Presentation

A novel paper-based substrate for coffee ring augmented surface-enhanced Raman spectroscopy

Anna Rourke, Alec Walter, Braden Carroll, Anita Mahadevan-Jansen, Andrea Locke

Proceedings Volume PC11968, PC1196802 (2022) https://doi.org/10.1117/12.2609871

KEYWORDS: Surface enhanced Raman spectroscopy, Raman spectroscopy, Nanoparticles, Bacteria, Scanning electron microscopy, Point-of-care devices, Modulation, Gold, Biological research

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Proceedings Article | 9 March 2022 Presentation

Presentation

Spectral imaging for intraoperative nerve visualization during thyroid surgery

Graham Throckmorton, Ezekiel Haugen, Justin Baba, Carmen Solórzano, Anita Mahadevan-Jansen

Proceedings Volume PC11949, PC1194909 (2022) https://doi.org/10.1117/12.2607407

KEYWORDS: Surgery, Nerve, Visualization, Imaging spectroscopy, Imaging systems, Tissues, Light, Hyperspectral imaging, System identification, Optical properties

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Proceedings Article | 9 March 2022 Presentation

Presentation

Ex vivo determination of nerve and surrounding tissue optical properties in rats and human cadavers for nerve-sparing surgical applications

Ezekiel Haugen, Graham Throckmorton, Alec Walter, Zaiyang Guo, Justin Baba, Anita Mahadevan-Jansen

Proceedings Volume PC11949, PC119490D (2022) https://doi.org/10.1117/12.2608860

KEYWORDS: Nerve, Optical properties, Tissue optics, Tissues, Scattering, Absorption, Laser scattering, Injuries, Visualization, Transmittance

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Proceedings Article | 9 March 2022 Presentation

Presentation

Is near infrared autofluorescence detection beneficial for parathyroidectomies? A randomized single center clinical trial

Giju Thomas, Colleen Kiernan, Anita Mahadevan-Jansen, Carmen Solórzano

Proceedings Volume PC11949, PC1194906 (2022) https://doi.org/10.1117/12.2610034

KEYWORDS: Surgery, Clinical trials, Near infrared, Visualization, Biopsy, Biological research

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Presentation

Label-free parathyroid gland identification during pediatric neck surgeries with near infrared autofluorescence detection

Giju Thomas, Parker Willmon, Ryan Belcher, Monica Lopez, Harold Lovvorn, Naira Baregamian, Carmen Solórzano, Anita Mahadevan-Jansen

Proceedings Volume PC11935, PC1193503 (2022) https://doi.org/10.1117/12.2610564

KEYWORDS: Surgery, Neck, Tissues, Near infrared, Fiber optics, Visualization, Fiber optics tests

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Proceedings Article | 7 March 2022 Presentation

Presentation

Computational modeling of photomechanical effects during infrared neural stimulation

Mayna Nguyen, Chad Oian, Anita Mahadevan-Jansen, E. Duco Jansen

Proceedings Volume PC11947, PC1194707 (2022) https://doi.org/10.1117/12.2607633

KEYWORDS: Infrared radiation, Infrared photography, Computational modeling

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Proceedings Article | 7 March 2022 Presentation

Presentation

Non-invasive detection and characterization of otitis media causing bacteria and bacterial biofilms through Raman spectroscopy and optical coherence tomography

Farzana Zaki, Andrea Locke, Sean Fitzgerald, Kavya Sudhir, Guillermo Monroy, Honggu Choi, Jungeun Won, Stephen Boppart, Anita Mahadevan-Jansen

Proceedings Volume PC11935, PC1193502 (2022) https://doi.org/10.1117/12.2608410

KEYWORDS: Optical coherence tomography, Raman spectroscopy, Bacteria, Ear, Remote sensing, Diagnostics, Spectroscopy, Resistance, Refractive index, Real time imaging

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Presentation

Translation of a label-free approach to surgical guidance

Anita Mahadevan-Jansen

Proceedings Volume PC11943, PC1194301 (2022) https://doi.org/10.1117/12.2617791

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Presentation

Comparing electrical and infrared neural stimulation for intraoperative nerve monitoring

Graham Throckmorton, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume PC11947, PC1194702 (2022) https://doi.org/10.1117/12.2607512

KEYWORDS: Nerve, Infrared radiation, Injuries, Tissue optics, Surgery, Performance modeling, In vivo imaging, Genetics, Damage detection, Axons

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Proceedings Article | 7 March 2022 Presentation

Presentation

Spatially offset Raman spectroscopy for non-invasive in vivo monitoring of hydration status

Anna Rourke, Laura Masson, Trevor Voss, Blair Hitchcock, Alda Burston, Anita Mahadevan-Jansen

Proceedings Volume PC11956, PC119560B (2022) https://doi.org/10.1117/12.2609897

KEYWORDS: Raman spectroscopy, In vivo imaging, Skin, Physiology, Optical fibers, Macromolecules, Fiber optics

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Presentation

Feasibility of Raman spectroscopy to characterize and detect oropharyngeal cancer

Sanidhya Tripathi, Sean Fitzgerald, Giju Thomas, Justin Shinn, Carey Wood, Young Kim, Anita Mahadevan-Jansen

Proceedings Volume PC11957, PC119570G (2022) https://doi.org/10.1117/12.2609197

KEYWORDS: Raman spectroscopy, Cancer, Tissues, Tumors, Remote sensing, Machine learning, Light scattering, Tumor growth modeling, Tongue, Spectroscopy

Read Abstract +

Proceedings Article | 7 December 2021 Paper

Paper

Combined fingerprint and high wavenumber spatially offset Raman spectroscopy for depth-resolved hydration and biochemical assessment

Laura Masson, Rekha Gautam, Andrea Locke, Giju Thomas, Anita Mahadevan-Jansen

Proceedings Volume 11919, 119191P (2021) https://doi.org/10.1117/12.2614933

KEYWORDS: Raman spectroscopy, Scattering, Remote sensing, Raman scattering, Optical phantoms, Monte Carlo methods, Tissue optics, Sensors, Semiconductor lasers, Molecules

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SPIE Journal Paper | 31 March 2021 Open Access

Open Access

Identifying optimal parameters for infrared neural stimulation in the peripheral nervous system

Graham Throckmorton, Jonathan Cayce, Zane Ricks, Wilson Adams, E. Duco Jansen, Anita Mahadevan-Jansen

NPh, Vol. 8, Issue 01, 015012, (March 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.015012

KEYWORDS: Semiconductor lasers, Nerve, Infrared radiation, Pulsed laser operation, Diodes, Safety, Neurophotonics, Laser damage threshold, Laser systems engineering, Absorption

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Laser-induced heating modulates microglial calcium signaling

John Logan Jenkins, Wilson Adams, Jeremy Ford, Sam Evans, Anita Mahadevan-Jansen, Mark Hutchinson, Duco Jansen

Proceedings Volume 11629, 1162913 (2021) https://doi.org/10.1117/12.2588775

KEYWORDS: Calcium, Modulation, Cell death, Infrared radiation, Pulsed laser operation, Optical fibers, Nervous system, Microscopy, Luminescence, Forward looking infrared

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Proceedings Article | 5 March 2021 Presentation

Presentation

Assessing a fiber probe-based approach to detect near infrared fluorescence for identifying and preserving parathyroid glands during neck surgeries

Giju Thomas, Emmanuel Mannoh, Melinda Sanders, Colleen Kiernan, Naira Baregamian, Carmen Solorzano, Anita Mahadevan-Jansen

Proceedings Volume 11631, 116310U (2021) https://doi.org/10.1117/12.2576823

KEYWORDS: Surgery, Near infrared, Luminescence, Fluorescence spectroscopy, Neck, Measurement devices, Indocyanine green

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Proceedings Article | 5 March 2021 Presentation

Presentation

Saliva characterization of eosinophilic esophagitis via surface enhanced Raman spectroscopy

Andrea Locke, Girish Hiremath, Regina Tyree, Anita Mahadevan-Jansen

Proceedings Volume 11651, 116510B (2021) https://doi.org/10.1117/12.2579054

KEYWORDS: Surface enhanced Raman spectroscopy, Diagnostics, Control systems, Biopsy, Visualization, Proteins, Principal component analysis, Esophagus

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

A multimodal imaging system for label-free parathyroid gland identification and vascularity assessment

Emmanuel Mannoh, Logan Parker, Giju Thomas, Carmen Solórzano, Anita Mahadevan-Jansen

Proceedings Volume 11631, 116310W (2021) https://doi.org/10.1117/12.2583235

KEYWORDS: Imaging systems, Multimodal imaging, Image segmentation, Surgery, Laser speckle contrast imaging, Visualization, Tissues, Speckle, Ranging, Near infrared

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Proceedings Article | 5 March 2021 Presentation

Presentation

Stimulation of Schwann cells by infrared pulsed stimulation

Ana Borrachero-Conejo, Wilson Adams, Graham Throckmorton, John Jenkins, Anita Mahadevan-Jansen

Proceedings Volume 11629, 116290N (2021) https://doi.org/10.1117/12.2583219

KEYWORDS: Infrared radiation, Modulation, Physiology, Nervous system, Nerve, Infrared imaging, In vitro testing, Glia, Calcium

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Infrared modulation of ionic and water dynamics of astroglial cells

Ana Borrachero-Conejo, Wilson Adams, Emanuela Saracino, Tamara Posati, Maria Mola, Grazia Nicchia, Valentina Benfenati, Anita Mahadevan-Jansen

Proceedings Volume 11640, 116400A (2021) https://doi.org/10.1117/12.2583139

KEYWORDS: Infrared radiation, Modulation, Pathology, Brain, Physiology, Pharmacology, Neurotransmitters, Luminescence, Ischemia, Ions

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Proceedings Article | 5 March 2021 Presentation

Presentation

Non-invasive detection and characterization of Otitis Media with Raman spectroscopy

Sean Fitzgerald, Andrea Locke, Anita Mahadevan-Jansen, Oscar Ayala

Proceedings Volume 11631, 1163106 (2021) https://doi.org/10.1117/12.2577252

KEYWORDS: Raman spectroscopy, Ear, Remote sensing, Bragg cells, Tissue optics, Visualization, Laser sources, In vivo imaging, Diagnostics

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Multimodal intrinsic contrast imaging for nerve discrimination in vivo

Graham Throckmorton, Justin Baba, Anita Mahadevan-Jansen

Proceedings Volume 11631, 116310B (2021) https://doi.org/10.1117/12.2576531

KEYWORDS: Nerve, In vivo imaging, Multimodal imaging, Imaging systems, Diffuse reflectance spectroscopy, Polarization, Imaging spectroscopy, Visualization, Tissues, Surgery

Read Abstract +

Proceedings Article | 10 March 2020 Presentation

Presentation

Probing the mechanisms of infrared neural stimulation with stimulated Raman scattering microscopy (Conference Presentation)

Wilson Adams, Rekha Gautam, Graham Throckmorton, Laura Masson, Jeremy Ford, John Logan Jenkins, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 11252, 1125204 (2020) https://doi.org/10.1117/12.2545228

KEYWORDS: Infrared radiation, Raman scattering, Infrared imaging, Microscopy, Raman spectroscopy, Imaging spectroscopy, Spectroscopy, Electrodynamics, Infrared signatures, Physiology

Read Abstract +

Proceedings Article | 9 March 2020 Presentation

Presentation

Comparing the efficacy of infrared diode and Ho:YAG lasers for infrared neural stimulation (Conference Presentation)

Graham Throckmorton, Wilson Adams, Zane Ricks, Jonathan Cayce, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 11227, 112270R (2020) https://doi.org/10.1117/12.2546270

KEYWORDS: Semiconductor lasers, Infrared radiation, Diodes, Infrared lasers, Laser damage threshold, Tissue optics, Animal model studies, Pulsed laser operation, In vivo imaging, Nerve

Read Abstract +

Proceedings Article | 9 March 2020 Presentation

Presentation

Astrocyte sensitivity to pulsed infrared light: molecular, physiological, and mechanistic insights (Conference Presentation)

Wilson Adams, Ana Borrachero-Conejo, Emanuela Saracino, Manqing Wang, Tamara Posati, Graham Throckmorton, John Logan Jenkins, Jeremy Ford, Roberto Zamboni, Marco Caprini, Grazia Paola Nicchia, E. Duco Jansen, Valentina Benfenati, Anita Mahadevan-Jansen

Proceedings Volume 11227, 112270N (2020) https://doi.org/10.1117/12.2545237

KEYWORDS: Infrared radiation, Infrared imaging, Thermography, Brain, Calcium, Receptors, Luminescence, Proteins, In vitro testing, Short wave infrared radiation

Read Abstract +

Proceedings Article | 9 March 2020 Presentation

Presentation

Nonlinear optical microscopy of lipogenesis and metabolism in HER2+ breast cancer (Conference Presentation)

Sean Fitzgerald, Giju Thomas, Anita Mahadevan-Jansen

Proceedings Volume 11216, 112160D (2020) https://doi.org/10.1117/12.2546467

KEYWORDS: Tumors, Breast cancer, Mammography, Phototherapy, 3D modeling, Tumor growth modeling, Cancer, Resistance, 3D image processing, Electron transport

Read Abstract +

Proceedings Article | 9 March 2020 Presentation

Presentation

Comparing cervical maturation in preterm and term birth mouse models with Raman spectroscopy (Conference Presentation)

Rekha Gautam, Jennifer Herington, Naoko Brown, Wilson Adam, Jackson Rogers, Jen Bateman, Christine O'Brien, Jeff Reese, Anita Mahadevan-Jansen

Proceedings Volume 11236, 112360W (2020) https://doi.org/10.1117/12.2551333

Read Abstract +

Proceedings Article | 7 March 2019 Presentation

Presentation

Navigating the leap from lab to market for a parathyroid identification device: an academic’s perspective (Conference Presentation)

Giju Thomas, Melanie McWade, Constantine Paras, Alexa Magner, Tyler Metcalf, Emmanuel Mannoh, Melinda Sanders, Lisa White, James Broome, Lawrence Shirley, John Phay, Naira Baregamian, Carmen Solorzano, Adnan Abbas, Roshan Shetty, Anita Mahadevan-Jansen

Proceedings Volume 10868, 108680W (2019) https://doi.org/10.1117/12.2522358

KEYWORDS: Surgery, Regulatory submissions, Near infrared, Prototyping, Medical devices

Read Abstract +

Proceedings Article | 7 March 2019 Presentation

Presentation

A combined autofluorescence and laser speckle contrast imaging system for parathyroid surgical guidance (Conference Presentation)

Emmanuel Mannoh, Ma Luo, Giju Thomas, Carmen Solórzano, Anita Mahadevan-Jansen

Proceedings Volume 10868, 108680P (2019) https://doi.org/10.1117/12.2508075

KEYWORDS: Laser speckle contrast imaging, Imaging systems, Blood, Calcium, Tissues, Algorithm development, Luminescence, Spectroscopy, Neck, Speckle

Read Abstract +

Proceedings Article | 7 March 2019 Presentation

Presentation

Comparing the efficacy and safety of infrared neural stimulation at 1450 nm and 1875 nm (Conference Presentation)

Graham Throckmorton, Wilson Adams, Zane Ricks, Jonathan Cayce, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 10866, 108660G (2019) https://doi.org/10.1117/12.2508055

KEYWORDS: Safety, Infrared radiation, Tissues, Genetics, Laser energy, Action potentials, In vivo imaging, Nerve, Clinical research

Read Abstract +

Proceedings Article | 4 March 2019 Presentation

Presentation

Multiplexed surface-enhanced Raman immunoimaging in vivo with gold nanostars (Conference Presentation)

Yu-Chuan Ou, Joseph Webb, Christine O'Brien, Isaac Pence, Eugene Lin, Eden Paul, Ethan Lippmann, Anita Mahadevan-Jansen, Rizia Bardhan

Proceedings Volume 10894, 108940G (2019) https://doi.org/10.1117/12.2506699

KEYWORDS: Raman spectroscopy, Gold, Multiplexing, In vivo imaging, Surface enhanced Raman spectroscopy, Imaging spectroscopy, Receptors, Molecules, Tumors, Nanostructures

Read Abstract +

SPIE Journal Paper | 30 October 2018 Open Access

Open Access

Challenges and opportunities in neurophotonics discussed at the International Conference on Biophotonics 2017

Mark Hutchinson, Paul Stoddart, Anita Mahadevan-Jansen

NPh, Vol. 5, Issue 04, 040402, (October 2018) https://doi.org/10.1117/12.10.1117/1.NPh.5.4.040402

KEYWORDS: Brain, Neurophotonics, Biomedical optics, Modulation, Neuroscience, Nervous system, Infrared radiation, Neurons, Medicine, Neurological disorders

Read Abstract +

Proceedings Article | 14 March 2018 Presentation

Presentation

Excitability of astrocyte in vitro with infrared neural stimulation (Conference Presentation)

Wilson Adams, Manqing Wang, Ana Borrachero-Conejo, Emanuela Saracino, Roberto Zamboni, Valentina Benfenati, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 10482, 104820D (2018) https://doi.org/10.1117/12.2291246

KEYWORDS: Infrared imaging, Infrared radiation, Calcium, Transient nonlinear optics, Brain, Thermography, In vivo imaging, In vitro testing, Modulation, Neurophotonics

Read Abstract +

SPIE Journal Paper | 2 March 2018

Development of a modular fluorescence overlay tissue imaging system for wide-field intraoperative surgical guidance

John Quan Minh Nguyen, Melanie McWade, Giju Thomas, Bryce Beddard, Jennifer Herington, Bibhash C. Paria, Herbert Schwartz, Jennifer Halpern, Ginger Holt, Anita Mahadevan-Jansen

JMI, Vol. 5, Issue 02, 021220, (March 2018) https://doi.org/10.1117/12.10.1117/1.JMI.5.2.021220

KEYWORDS: Luminescence, Imaging systems, Tumors, Tissues, Near infrared, Signal to noise ratio, Veins, Calibration, In vivo imaging, Surgery

Read Abstract +

Proceedings Article | 20 February 2018 Paper

Paper

Development of an optical fiber SERS microprobe for minimally invasive sensing applications

Md Abdullah Al Mamun, Saulius Juodkazis, Anita Mahadevan-Jansen, Paul Stoddart

Proceedings Volume 10501, 1050102 (2018) https://doi.org/10.1117/12.2289227

KEYWORDS: Raman spectroscopy, Optical filters, Silica, Raman scattering, Surface enhanced Raman spectroscopy, Optical fibers, Signal detection, Optical filtering, Light scattering, Scattering

Read Abstract +

Proceedings Article | 19 April 2017 Presentation

Presentation

Exploring infrared neural stimulation with multimodal nonlinear imaging (Conference Presentation)

Wilson Adams, Anita Mahadevan-Jansen

Proceedings Volume 10051, 100510U (2017) https://doi.org/10.1117/12.2256695

KEYWORDS: Thermography, Infrared imaging, Coherence imaging, Infrared radiation, Raman spectroscopy, Multimodal imaging, Mid-IR, Tissues, Luminescence, Second-harmonic generation

Read Abstract +

Proceedings Article | 19 April 2017 Presentation

Presentation

SWIR dispersive Raman spectroscopy for discrimination of normal and malignant kidney tissue (Conference Presentation)

Miki Haifler, Isaac Pence, Amnon Zisman, Robert Uzzo, Richard Greenberg, Alexander Kutikov, Marc Smaldone, David Chen, Rosalia Viterbo, Benjamin Ristau, Anita Mahadevan-Jansen, Alexander Dumont, Chetan Patil

Proceedings Volume 10038, 100380O (2017) https://doi.org/10.1117/12.2256617

KEYWORDS: Kidney, Remote sensing, Tissues, Tissue optics, Raman spectroscopy, Cancer, Computed tomography, Surgery, Tomography, Short wave infrared radiation

Read Abstract +

Proceedings Article | 19 April 2017 Presentation

Presentation

Intraoperative detection of parathyroid gland perfusion during endocrine surgeries (Conference Presentation)

Emmanuel Mannoh, Giju Thomas, Carmen Solorzano, Anita Mahadevan-Jansen

Proceedings Volume 10054, 1005415 (2017) https://doi.org/10.1117/12.2261890

KEYWORDS: Surgery, Blood, Objectives, Cameras, Speckle, Transplantation, Optical inspection, Laser speckle imaging, Laser sources, Zoom lenses

Read Abstract +

Proceedings Article | 30 March 2017 Paper

Paper

Neural responses of rat cortical layers due to infrared neural modulation and photoablation of thalamocortical brain slices

J. Logan Jenkins, Chris Kao, Jonathan Cayce, Anita Mahadevan-Jansen, E. Duco Jansen

Proceedings Volume 10052, 100520L (2017) https://doi.org/10.1117/12.2256302

KEYWORDS: Infrared radiation, Neurons, Brain, Nervous system, Modulation, Luminescence, Laser ablation, Laser cutting, Tissues, Electrodes

Read Abstract +

Proceedings Article | 8 March 2016 Presentation + Paper

Presentation + Paper

Identification of bacteria causing acute otitis media using Raman microspectroscopy

Oscar Ayala, Catherine Wakeman, Eric Skaar, Anita Mahadevan-Jansen

Proceedings Volume 9704, 97040U (2016) https://doi.org/10.1117/12.2213563

KEYWORDS: Raman spectroscopy, Bacteria, Diagnostics, Confocal microscopy, Microscopes, Pathogens, In vitro testing, Ear, Signal to noise ratio

Read Abstract +

Proceedings Article | 7 March 2016 Paper

Paper

Discrimination of inflammatory bowel disease using Raman spectroscopy and linear discriminant analysis methods

Hao Ding, Ming Cao, Andrew DuPont, Larry Scott, Sushovan Guha, Shashideep Singhal, Mamoun Younes, Isaac Pence, Alan Herline, David Schwartz, Hua Xu, Anita Mahadevan-Jansen, Xiaohong Bi

Proceedings Volume 9704, 97040W (2016) https://doi.org/10.1117/12.2225299

KEYWORDS: Raman spectroscopy, Feature selection, Inflammation, Critical dimension metrology, In vivo imaging, Therapeutics, Diagnostics, Colon, Chemical analysis, Statistical analysis, Principal component analysis, Remote sensing, Fiber optics, Health sciences

Read Abstract +

Proceedings Article | 9 March 2015 Paper

Paper

Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy

Christine O'Brien, Elizabeth Vargis, Chris Slaughter, Amy Rudin, Jennifer Herington, Kelly Bennett, Jeff Reese, Anita Mahadevan-Jansen

Proceedings Volume 9303, 93032F (2015) https://doi.org/10.1117/12.2077775

KEYWORDS: Raman spectroscopy, Cervix, In vivo imaging, Molecules, Photons, Proteins, Statistical analysis, Analytical research, Diagnostics, Fetus

Read Abstract +

Proceedings Article | 4 March 2015 Paper

Paper

Imaging system design for surgical guidance with near-infrared autofluorescence

Melanie McWade, Isaac Pence, Constantine Paras, Anita Mahadevan-Jansen

Proceedings Volume 9313, 931303 (2015) https://doi.org/10.1117/12.2076632

KEYWORDS: Imaging systems, Near infrared, Luminescence, CCD cameras, Endoscopes, Cameras, Tissues, Spatial resolution, Surgery, Fluorescence spectroscopy

Read Abstract +

Proceedings Article | 26 February 2015 Paper

Paper

Bone tissue heterogeneity is associated with fracture toughness: a polarization Raman spectroscopy study

Alexander Makowski, Mathilde Granke, Sasidhar Uppuganti, Anita Mahadevan-Jansen, Jeffry Nyman

Proceedings Volume 9303, 930341 (2015) https://doi.org/10.1117/12.2080350

KEYWORDS: Bone, Raman spectroscopy, Polarization, Resistance, Carbonates, Collagen, Tissues, Statistical analysis, Tissue optics, Polishing

Read Abstract +

SPIE Journal Paper | 23 February 2015 Open Access

Open Access

Infrared neural stimulation of human spinal nerve roots in vivo

Jonathan Cayce, Jonathon Wells, Jonathan Malphrus, Chris Kao, Sharon Thomsen, Noel Tulipan, Peter Konrad, E. Duco Jansen, Anita Mahadevan-Jansen

NPh, Vol. 2, Issue 01, 015007, (February 2015) https://doi.org/10.1117/12.10.1117/1.NPh.2.1.015007

KEYWORDS: Nerve, Infrared radiation, Tissues, Electromyography, Safety, In vivo imaging, Optical fibers, Surgery, Diagnostics, Tissue optics

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SPIE Journal Paper | 17 November 2014 Open Access

Open Access

Polarization in Raman spectroscopy helps explain bone brittleness in genetic mouse models

Alexander Makowski, Isaac Pence, Sasidhar Uppuganti, Ahbid Zein-Sabatto, Meredith Huszagh, Anita Mahadevan-Jansen, Jeffry Nyman

JBO, Vol. 19, Issue 11, 117008, (November 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.11.117008

KEYWORDS: Bone, Remote sensing, Polarization, Raman spectroscopy, Crystals, Principal component analysis, Tissues, Collagen, Genetics, Mouse models

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SPIE Journal Paper | 12 November 2014 Open Access

Open Access

Special Section Guest Editorial: Vibrational Spectroscopy and Imaging

Anita Mahadevan-Jansen, Michael Morris, Wolfgang Petrich

JBO, Vol. 19, Issue 11, 111601, (November 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.11.111601

KEYWORDS: Imaging spectroscopy, Spectroscopy, Raman spectroscopy, Biomedical optics, Molecules, Raman scattering, Biomedical engineering, Infrared radiation, Quantum cascade lasers, Signal detection

SPIE Journal Paper | 12 September 2014 Open Access

Open Access

Special Section Guest Editorial: The BRAIN Initiative

Anna Devor, Anna Roe, Anita Mahadevan-Jansen, David A. Boas

NPh, Vol. 1, Issue 01, 011001, (September 2014) https://doi.org/10.1117/12.10.1117/1.NPh.1.1.011001

KEYWORDS: Brain, Neuroscience, Biomedical optics, Radiology, Neuroimaging, Biomedical engineering, Tissue optics, Neurophotonics, Ocean optics, Photonics

SPIE Journal Paper | 16 June 2014 Open Access

Open Access

Development of Raman spectral markers to assess metastatic bone in breast cancer

Hao Ding, Jeffry Nyman, Julie Sterling, Daniel Perrien, Anita Mahadevan-Jansen, Xiaohong Bi

JBO, Vol. 19, Issue 11, 111606, (June 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.11.111606

KEYWORDS: Bone, Raman spectroscopy, Tumors, Breast cancer, Crystals, Tissues, Remote sensing, Minerals, Carbonates, Radiography

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Proceedings Article | 4 March 2014 Paper

Paper

Endoscopy-coupled Raman spectroscopy for in vivo discrimination of inflammatory bowel disease

I. Pence, Q. Nguyen, X. Bi, A. Herline, D. Beaulieu, S. Horst, D. Schwartz, A. Mahadevan-Jansen

Proceedings Volume 8939, 89390R (2014) https://doi.org/10.1117/12.2042795

KEYWORDS: Raman spectroscopy, In vivo imaging, Endoscopy, Endoscopes, Microlens, Tissues, Raman scattering, Diagnostics, Colon, Statistical analysis

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SPIE Journal Paper | 4 February 2014 Open Access

Open Access

Evaluating HER2 amplification status and acquired drug resistance in breast cancer cells using Raman spectroscopy

Xiaohong Bi, Brent Rexer, Carlos Arteaga, Mingsheng Guo, Anita Mahadevan-Jansen

JBO, Vol. 19, Issue 02, 025001, (February 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.2.025001

KEYWORDS: Breast cancer, Raman spectroscopy, Resistance, Cancer, Remote sensing, Statistical analysis, Proteins, Receptors, Oncology, Breast

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SPIE Journal Paper | 24 May 2013 Open Access

Open Access

Polarization control of Raman spectroscopy optimizes the assessment of bone tissue

Alexander Makowski, Chetan Patil, Anita Mahadevan-Jansen, Jeffry Nyman

JBO, Vol. 18, Issue 05, 055005, (May 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.5.055005

KEYWORDS: Polarization, Bone, Remote sensing, Raman spectroscopy, Collagen, Minerals, Tissues, Carbonates, Data modeling, Microscopes

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Proceedings Article | 8 March 2013 Paper

Paper

Polarization Raman spectroscopy to explain rodent models of brittle bone

Alexander Makowski, Jeffry Nyman, Anita Mahadevan-Jansen

Proceedings Volume 8565, 85656L (2013) https://doi.org/10.1117/12.2006487

KEYWORDS: Bone, Raman spectroscopy, Polarization, Collagen, Minerals, Anisotropy, Molecules, Confocal microscopy, Microscopes, Diagnostics

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SPIE Journal Paper | 1 November 2011 Open Access

Open Access

Sensitivity of Raman spectroscopy to normal patient variability

Elizabeth Vargis, Anita Mahadevan-Jansen, Teresa Byrd, Quinisha Logan, Dineo Khabele

JBO, Vol. 16, Issue 11, 117004, (November 2011) https://doi.org/10.1117/12.10.1117/1.3646210

KEYWORDS: Raman spectroscopy, Cervix, Brain-machine interfaces, Cervical cancer, In vivo imaging, Statistical analysis, Infrared spectroscopy, Breast, In vitro testing, Tissues

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SPIE Journal Paper | 1 July 2011 Open Access

Open Access

Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation

Matthew Keller, Elizabeth Vargis, Anita Mahadevan-Jansen, Nara de Matos Granja, Robert Wilson, Mary-Ann Mycek, Mark Kelley

JBO, Vol. 16, Issue 07, 077006, (July 2011) https://doi.org/10.1117/12.10.1117/1.3600708

KEYWORDS: Tumors, Tissues, Breast, Raman spectroscopy, Signal to noise ratio, Sensors, Natural surfaces, Tissue optics, Composites, Monte Carlo methods

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SPIE Journal Paper | 1 June 2011 Open Access

Open Access

Near-infrared autofluorescence for the detection of parathyroid glands

Constantine Paras, Matthew Keller, Anita Mahadevan-Jansen, Lisa White, John Phay

JBO, Vol. 16, Issue 06, 067012, (June 2011) https://doi.org/10.1117/12.10.1117/1.3583571

KEYWORDS: Luminescence, Tissues, Surgery, Near infrared, In vivo imaging, Neck, Signal detection, Biomedical optics, Optical inspection, Ultrasonography

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Proceedings Article | 2 March 2011 Paper

Paper

Using Raman spectroscopy to study the onset of labor: a pilot study

Elizabeth Vargis, C. Nathan Webb, B. Paria, Kelly Bennett, Jeff Reese, Ayman Al-Hendy, Anita Mahadevan-Jansen

Proceedings Volume 7890, 789019 (2011) https://doi.org/10.1117/12.881239

KEYWORDS: Raman spectroscopy, Cervix, Remote sensing, Collagen, Molecules, In vivo imaging, Visualization, Tissues, Photons, Data acquisition

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SPIE Journal Paper | 1 January 2011 Open Access

Open Access

Integrated system for combined Raman spectroscopy-spectral domain optical coherence tomography

Chetan Patil, Jeroen Kalkman, Dirk Faber, Jeffry Nyman, Ton van Leeuwen, Anita Mahadevan-Jansen

JBO, Vol. 16, Issue 1, 011007, (January 2011) https://doi.org/10.1117/12.10.1117/1.3520132

KEYWORDS: Optical coherence tomography, Raman spectroscopy, Remote sensing, Tissues, Skin, Sensors, Imaging systems, Spectrographs, Retina, System integration

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Proceedings Article | 3 March 2010 Paper

Paper

Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-spectral domain optical coherence tomography (RS-SDOCT)

Chetan Patil, Jeroen Kalkman, Dirk Faber, John Penn, Ton van Leeuwen, Anita Mahadevan-Jansen

Proceedings Volume 7550, 75501B (2010) https://doi.org/10.1117/12.843106

KEYWORDS: Optical coherence tomography, Raman spectroscopy, Retina, Remote sensing, Tissues, Spectrographs, Instrument modeling, Eye, Sensors, Oxygen

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Proceedings Article | 3 March 2010 Paper

Paper

Characterization of bone quality in prostate cancer bone metastases using Raman spectroscopy

Xiaohong Bi, Chetan Patil, Colm Morrissey, Martine Roudier, Anita Mahadevan-Jansen, Jeffry Nyman

Proceedings Volume 7548, 75484L (2010) https://doi.org/10.1117/12.853551

KEYWORDS: Bone, Raman spectroscopy, Prostate cancer, Crystals, Minerals, Tumors, Collagen, Carbonates, Tissues, Principal component analysis

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Proceedings Article | 2 March 2010 Paper

Paper

A clinical probe for combined Raman spectroscopy-optical coherence tomography (RS-OCT) of the skin cancers

Chetan Patil, Harish Krishnamoorthi, Darrel Ellis, Ton van Leeuwen, Anita Mahadevan-Jansen

Proceedings Volume 7548, 75480L (2010) https://doi.org/10.1117/12.843708

KEYWORDS: Raman spectroscopy, Optical coherence tomography, Skin, Skin cancer, Remote sensing, Signal detection, Optical filters, Cancer, Confocal microscopy, Imaging spectroscopy

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Proceedings Article | 23 February 2010 Paper

Paper

Effects of temperature on fluorescence in human tissue

D. Masters, Alex Walsh, A. Welch, Anita Mahadevan-Jansen

Proceedings Volume 7562, 75620V (2010) https://doi.org/10.1117/12.842488

KEYWORDS: Luminescence, Tissues, Optical properties, In vitro testing, In vivo imaging, Temperature metrology, Skin, Monte Carlo methods, Tissue optics, Breast

Read Abstract +

Proceedings Article | 12 February 2010 Paper

Paper

Detecting changes during pregnancy with Raman spectroscopy

Elizabeth Vargis, Kesha Robertson, Ayman Al-Hendy, Jeff Reese, Anita Mahadevan-Jansen

Proceedings Volume 7560, 75600H (2010) https://doi.org/10.1117/12.843005

KEYWORDS: Raman spectroscopy, Cervix, Remote sensing, Molecules, In vivo imaging, Collagen, Tissues, Photons, Data acquisition, Cancer

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Proceedings Article | 12 February 2010 Paper

Paper

The effect of temperature of fluorescence: an animal study

Alex Walsh, Bart Masters, Duco Jansen, A. Welch, Anita Mahadevan-Jansen

Proceedings Volume 7562, 75620W (2010) https://doi.org/10.1117/12.842578

KEYWORDS: Luminescence, Tissues, Temperature metrology, Optical properties, Diffuse reflectance spectroscopy, Skin, Eye, Collagen, Cameras, Tissue optics

Read Abstract +

Proceedings Article | 12 February 2010 Paper

Paper

Determination of HER2 amplification status in breast cancer cells using Raman spectroscopy

Xiaohong Bi, Brent Rexer, Carlos Arteaga, Mingsheng Guo, Ming Li, Anita Mahadevan-Jansen

Proceedings Volume 7560, 75600C (2010) https://doi.org/10.1117/12.858804

KEYWORDS: Raman spectroscopy, Breast cancer, Tissues, Data modeling, Receptors, Proteins, Algorithm development, Cancer, Breast, Confocal microscopy

Read Abstract +

SPIE Journal Paper | 1 November 2009 Open Access

Open Access

Combined optical and electrical stimulation of neural tissue in vivo

Austin Duke, Jonathan Cayce, Jonathan Malphrus, Peter Konrad, Anita Mahadevan-Jansen, E. Duco Jansen

JBO, Vol. 14, Issue 06, 060501, (November 2009) https://doi.org/10.1117/12.10.1117/1.3257230

KEYWORDS: Tissue optics, Infrared radiation, Nerve, Ocean optics, Electrodes, Laser tissue interaction, In vivo imaging, Laser induced damage, Laser damage threshold, Semiconductor lasers

Read Abstract +

Proceedings Article | 24 February 2009 Paper

Paper

Raman spectroscopy for assessment of bone quality in MMP-2 knockout mice

Xiaohong Bi, Jeffry Nyman, Chetan Patil, Philip Masui, Conor Lynch, Anita Mahadevan-Jansen

Proceedings Volume 7166, 71660B (2009) https://doi.org/10.1117/12.813928

KEYWORDS: Bone, Minerals, Raman spectroscopy, Crystals, Carbonates, Collagen, Remote sensing, Tissues, Crystallography, Genetics

Read Abstract +

Proceedings Article | 23 February 2009 Paper

Paper

A MEMS based handheld confocal microscope with Raman spectroscopy for in-vivo skin cancer diagnosis

Christopher Arrasmith, Chetan Patil, David Dickensheets, Anita Mahadevan-Jansen

Proceedings Volume 7169, 71690N (2009) https://doi.org/10.1117/12.812071

KEYWORDS: Confocal microscopy, Raman spectroscopy, Microscopes, In vivo imaging, Skin, Objectives, Mirrors, Microelectromechanical systems, Skin cancer, Reflectivity

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SPIE Journal Paper | 1 January 2009 Open Access

Open Access

Raman microspectroscopy for skin cancer detection in vitro

Chad Lieber, Shovan Majumder, D. Dean Billheimer, Darrel Ellis, Anita Mahadevan-Jansen

JBO, Vol. 13, Issue 02, 024013, (January 2009) https://doi.org/10.1117/12.10.1117/1.2899155

KEYWORDS: Raman spectroscopy, Skin, Tissues, Skin cancer, Confocal microscopy, Tissue optics, Melanoma, Imaging spectroscopy, In vitro testing, Pathology

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SPIE Journal Paper | 1 September 2008 Open Access

Open Access

Comparison of autofluorescence, diffuse reflectance, and Raman spectroscopy for breast tissue discrimination

Shovan Majumder, Matthew Keller, Fouad Boulos, Mark Kelley, Anita Mahadevan-Jansen

JBO, Vol. 13, Issue 05, 054009, (September 2008) https://doi.org/10.1117/12.10.1117/1.2975962

KEYWORDS: Tissues, Diffuse reflectance spectroscopy, Breast, Luminescence, Raman spectroscopy, Tissue optics, Diagnostics, Algorithm development, Spectroscopy, Pathology

Read Abstract +

Proceedings Article | 20 February 2008 Paper

Paper

Frontiers in optical stimulation of neural tissues: past, present, and future

Jonathon Wells, Mark Bendett, Jim Webb, Claus Richter, Agnella Izzo, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 6854, 68540B (2008) https://doi.org/10.1117/12.776988

KEYWORDS: Nerve, Tissues, Tissue optics, Electrodes, Safety, Neurons, Infrared radiation, Action potentials, Nervous system, Brain

Read Abstract +

Proceedings Article | 11 July 2007 Paper

Paper

Optical spectroscopy for therapeutic guidance in breast conserving therapy

Matthew Keller, Shovan Majumder, Mark Kelley, Ingrid Meszoely, Fouad Boulos, Anita Mahadevan-Jansen

Proceedings Volume 6628, 66280J (2007) https://doi.org/10.1117/12.729529

KEYWORDS: Tumors, Tissues, Luminescence, Breast, Diffuse reflectance spectroscopy, Reflectivity, Tissue optics, Imaging spectroscopy, Breast cancer, Optical spectroscopy

Read Abstract +

Proceedings Article | 7 February 2007 Paper

Paper

In vivo optical detection of brain tumor and tumor margin: a combined autofluorescence and diffuse reflectance spectroscopic study

Shovan Majumder, Steven Gebhart, Reid Thompson, Kyle Weaver, Mahlon Johnson, Wei-Chiang Lin, Anita Mahadevan-Jansen

Proceedings Volume 6430, 64300F (2007) https://doi.org/10.1117/12.724875

KEYWORDS: Tumors, Brain, Tissues, Diffuse reflectance spectroscopy, Algorithm development, Diagnostics, In vivo imaging, Spectroscopy, Luminescence, Reflectance spectroscopy

Read Abstract +

Proceedings Article | 6 February 2007 Paper

Paper

Optical detection of breast tumors: a comparison of diagnostic performance of autofluorescence, diffuse reflectance, and Raman spectroscopy

Shovan Majumder, Matthew Keller, Anita Mahadevan-Jansen

Proceedings Volume 6430, 64300C (2007) https://doi.org/10.1117/12.714638

KEYWORDS: Tissues, Breast, Diffuse reflectance spectroscopy, Raman spectroscopy, Luminescence, Diagnostics, Algorithm development, Tumors, Pathology, Tissue optics

Read Abstract +

Proceedings Article | 6 February 2007 Paper

Paper

Near-infrared Raman spectroscopy for in vivo diagnosis of cervical dysplasia: a probability-based multi-class diagnostic algorithm

Shovan Majumder, Elizabeth Kanter, Amy Robichaux Viehoever, Howard Jones, Anita Mahadevan-Jansen

Proceedings Volume 6430, 64300Q (2007) https://doi.org/10.1117/12.724873

KEYWORDS: Tissues, Raman spectroscopy, Diagnostics, Algorithm development, Cervix, Transform theory, Feature extraction, In vivo imaging, Spectroscopy, Cervical cancer

Read Abstract +

Proceedings Article | 1 March 2006 Paper

Paper

Biophysical mechanisms responsible for pulsed low-level laser excitation of neural tissue

Jonathon Wells, Chris Kao, Peter Konrad, Anita Mahadevan-Jansen, E. Duco Jansen

Proceedings Volume 6084, 60840X (2006) https://doi.org/10.1117/12.655239

KEYWORDS: Nerve, Laser tissue interaction, Tissue optics, Pulsed laser operation, Tissues, Temperature metrology, Alexandrite lasers, Natural surfaces, Absorption, Free electron lasers

Read Abstract +

Background/Objective: The traditional method of stimulating neural activity has been based on electrical methods and remains the gold standard to date despite inherent limitations. We have previously shown a new paradigm to in vivo neural activation based on pulsed infrared light, which provides a contact-free, spatially selective, artifact-free method without incurring tissue damage that may have significant advantages over electrical stimulation in a variety of diagnostic and therapeutic applications. The goal of this study was to investigate the physical mechanism of this phenomenon, which we propose is a photo-thermal effect from transient tissue temperature changes resulting in direct or indirect activation of transmembrane ion channels causing propagation of the action potential. Methods: Rat sciatic nerve preparation was stimulated in vivo with the Holmium:YAG laser (2.12μm), Free Electron Laser (2.1μm), Alexandrite laser (690nm), and the prototype for a solid state commercial laser nerve stimulator built by Aculight (1.87μm) to determine contributions of photobiological responses from laser tissue interactions, including temperature, pressure, electric field, and photochemistry, underlying the biophysical mechanism of stimulation. Single point temperature measurements were made with a microthermocouple adjacent to the excitation site, while an infrared camera was used for 2-D radiometry of the irradiated surface. Displacement from laser-induced pressure waves or thermoelastic expansion was measured using a PS-OCT system. Results: Results exclude a direct photochemical, electric field, or pressure wave effect as the mechanism of optical stimulation. Measurements show relative small contributions from thermoelastic expansion (300 nm) with the laser parameters used for nerve stimulation. The maximum change in tissue temperature is about 9°C (average increase of 3.66 °C) at stimulation threshold radiant exposures. Conclusion: Neural activation with pulsed laser-light occurs by a transient thermally induced mechanism. Future experiments will reveal if this effect is through direct membrane interaction or facilitated through an indirect effect leading to membrane depolarization.

Proceedings Article | 25 February 2006 Paper

Paper

Brain tumor demarcation with liquid-crystal tunable filter spectral imaging

Steven Gebhart, Anita Mahadevan-Jansen

Proceedings Volume 6080, 60800I (2006) https://doi.org/10.1117/12.653928

KEYWORDS: Imaging systems, Diffuse reflectance spectroscopy, Luminescence, Tissues, Brain, Neuroimaging, Imaging spectroscopy, Tumors, Spatial resolution, Liquid crystals

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Proceedings Article | 22 February 2006 Paper

Paper

Feasibility of Raman spectroscopy in vitro after 5-ALA-based fluorescence diagnosis in the bladder

M. Grimbergen, C. van Swol, R. van Moorselaar, A, Mahadevan-Jansen, N. Stone

Proceedings Volume 6078, 60781D (2006) https://doi.org/10.1117/12.655616

KEYWORDS: Raman spectroscopy, Biopsy, Luminescence, Bladder, Tissues, Tumors, In vitro testing, Algorithm development, Bladder cancer, Pathology

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SPIE Journal Paper | 1 November 2005 Open Access

Open Access

Application of infrared light for in vivo neural stimulation

Jonathon Wells, Chris Kao, E. Duco Jansen, Peter Konrad, Anita Mahadevan-Jansen

JBO, Vol. 10, Issue 06, 064003, (November 2005) https://doi.org/10.1117/12.10.1117/1.2121772

KEYWORDS: Nerve, Tissue optics, Absorption, Laser tissue interaction, Tissues, Free electron lasers, Infrared radiation, Neurons, Safety, In vivo imaging

Read Abstract +

SPIE Journal Paper | 1 May 2005 Open Access

Open Access

Infrared and Raman Spectroscopy

Michael Morris, Andrew Berger, Anita Mahadevan-Jansen

JBO, Vol. 10, Issue 03, 031101, (May 2005) https://doi.org/10.1117/12.10.1117/1.1906246

Proceedings Article | 23 March 2005 Paper

Paper

Instrumentation considerations in spectral imaging for tissue demarcation: comparing three methods of spectral resolution

Steven Gebhart, David Stokes, Tuan Vo-Dinh, Anita Mahadevan-Jansen

Proceedings Volume 5694, (2005) https://doi.org/10.1117/12.611351

KEYWORDS: Imaging systems, Signal to noise ratio, Imaging spectroscopy, Tissues, Optical filters, Luminescence, Spectral resolution, Tissue optics, Auto-fluorescence imaging, Tunable filters

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SPIE Journal Paper | 1 September 2004 Open Access

Open Access

In vivo assessment of thermal damage in the liver using optical spectroscopy

Clay Buttemere, Ravi Chari, Christopher Anderson, Kay Washington, Anita Mahadevan-Jansen, Wei-Chiang Lin

JBO, Vol. 9, Issue 05, (September 2004) https://doi.org/10.1117/12.10.1117/1.1779627

KEYWORDS: Luminescence, Tissues, Diffuse reflectance spectroscopy, Tissue optics, Liver, In vivo imaging, Blood, Absorption, In vitro testing, Spectroscopy

Read Abstract +

Proceedings Article | 1 July 2004 Paper

Paper

Handheld confocal Raman microspectrometer for in-vivo skin cancer measurement

Chad Lieber, Darrel Ellis, D. Billheimer, Anita Mahadevan-Jansen

Proceedings Volume 5321, (2004) https://doi.org/10.1117/12.533188

KEYWORDS: Raman spectroscopy, Confocal microscopy, Skin, Semiconductor lasers, In vitro testing, Mirrors, In vivo imaging, Skin cancer, Microscopes, Diagnostics

Read Abstract +

Proceedings Article | 22 July 2003 Paper

Paper

Feedback control of liver thermotherapy using optical spectroscopy

Clay Buttemere, Ravi Chari, Christopher Anderson, Anita Mahadevan-Jansen, Wei-Chiang Lin

Proceedings Volume 4958, (2003) https://doi.org/10.1117/12.479803

KEYWORDS: Tissues, Luminescence, Liver, Tissue optics, Diffuse reflectance spectroscopy, In vivo imaging, In vitro testing, Heat therapy, Thermal modeling, Tumors

Read Abstract +

Proceedings Article | 2 July 2003 Paper

Paper

Characterization of a spectral imaging system

Steven Gebhart, Wei-Chiang Lin, Anita Mahadevan-Jansen

Proceedings Volume 4959, (2003) https://doi.org/10.1117/12.479856

KEYWORDS: Imaging systems, Imaging spectroscopy, Luminescence, Tumors, Spatial resolution, Tissue optics, Spectral resolution, Tissues, Brain, Calibration

Read Abstract +

Proceedings Article | 27 March 2002 Paper

Paper

In vivo detection of cervical dysplasia with near-infrared Raman spectroscopy

Amy Robichaux, Chad Lieber, Heidi Shappell, Beth Huff, Howard Jones, Anita Mahadevan-Jansen

Proceedings Volume 4614, (2002) https://doi.org/10.1117/12.460793

KEYWORDS: Raman spectroscopy, Tissues, Pathology, In vivo imaging, Cervix, Principal component analysis, Algorithm development, Optical filters, Diagnostics, Electronic filtering

Read Abstract +

Proceedings Article | 2 July 2001 Paper

Paper

Brain tissue charcterization using spectral imaging: a potential clinical tool

Anita Mahadevan-Jansen, David Mongin, E. Duco Jansen, Dawn Pedrotty, Wei-Chiang Lin

Proceedings Volume 4259, (2001) https://doi.org/10.1117/12.432484

KEYWORDS: Brain, Tissues, Imaging spectroscopy, Tumors, Luminescence, Neuroimaging, Imaging systems, Tissue optics, Data acquisition, Optical spectroscopy

Read Abstract +

Proceedings Article | 4 June 2001 Paper

Paper

Intraoperative spectroscopic-guided brain tumor resection: reduction of blood contamination effects on tissue optical spectra

Wei-Chiang Lin, Anita Mahadevan-Jansen, E. Duco Jansen

Proceedings Volume 4254, (2001) https://doi.org/10.1117/12.427932

KEYWORDS: Blood, Tissue optics, Luminescence, Contamination, Tumors, Brain, Diffuse reflectance spectroscopy, Tissues, Monte Carlo methods, Optical spectroscopy

Read Abstract +

Proceedings Article | 8 May 2000 Paper

Paper

Diagnostic tool for early detection of ovarian cancers using Ramanspectroscopy

Chad Lieber, Kelly Molpus, Kevin Brader, Anita Mahadevan-Jansen

Proceedings Volume 3918, (2000) https://doi.org/10.1117/12.384934

KEYWORDS: Raman spectroscopy, Tissues, Ovarian cancer, Diagnostics, Luminescence, Algorithm development, Tumors, Pathology, Statistical analysis, In vitro testing

Read Abstract +

Proceedings Article | 3 May 2000 Paper

Paper

Spectroscopic-guided brain tumor resection

Wei-Chiang Lin, Steven Toms, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 3911, (2000) https://doi.org/10.1117/12.384896

KEYWORDS: Tumors, Brain, Tissues, Electroluminescence, Luminescence, Diffuse reflectance spectroscopy, Spectroscopy, In vivo imaging, Optical spectroscopy, Algorithm development

Read Abstract +

SPIE Journal Paper | 1 April 2000 Open Access

Open Access

Brain tumor demarcation using optical spectroscopy: an in vitro study

Wei-Chiang Lin, Steven Toms, Massoud Motamedi, E. Duco Jansen, Anita Mahadevan-Jansen

JBO, Vol. 5, Issue 02, (April 2000) https://doi.org/10.1117/12.10.1117/1.429989

KEYWORDS: Brain, Tumors, Tissues, Luminescence, Diffuse reflectance spectroscopy, Algorithm development, In vitro testing, Reflectivity, Optical spectroscopy, Spectroscopy

Proceedings Article | 6 December 1996 Paper

Paper

Detection of cervical precancer using optical spectroscopy (Extended Abstract)

Nirmala Ramanujam, Michele Follen-Mitchell, Anita Mahadevan-Jansen, Constantinos Pitris, Anant Agrawal, Sharon Thomsen, Gregg Staerkel, Thomas Wright, Rebecca Richards-Kortum

Proceedings Volume 2926, (1996) https://doi.org/10.1117/12.260814

KEYWORDS: Algorithm development, Raman spectroscopy, Tissues, Luminescence, Optical spectroscopy, Diagnostics, Fluorescence spectroscopy, Cervix, Target detection, In vivo imaging

Read Abstract +

SPIE Journal Paper | 2 January 1996 Open Access

Open Access

Raman spectroscopy for the detection of cancers and precancers

Anita Mahadevan-Jansen, Rebecca Richards-Kortum

JBO, Vol. 1, Issue 01, (January 1996) https://doi.org/10.1117/12.10.1117/12.227815

KEYWORDS: Raman spectroscopy, Tissues, Proteins, Cancer, Luminescence, Tissue optics, Optical fibers, Molecules, Breast, Tumors

Read Abstract +

Proceedings Article | 8 May 1995 Paper

Paper

Optical techniques for diagnosis of cervical precancers: a comparison of Raman and fluorescence spectroscopies

Anita Mahadevan-Jansen, Nirmala Ramanujam, Michele Follen-Mitchell, Anais Malpica, Sharon Thomsen, Rebecca Richards-Kortum

Proceedings Volume 2388, (1995) https://doi.org/10.1117/12.208469

KEYWORDS: Tissues, Raman spectroscopy, Luminescence, Algorithm development, Calibration, Inflammation, Diagnostics, In vivo imaging, Rhodamine, Fluorescence spectroscopy

Read Abstract +

Showing 5 of 105 publications

Proceedings Volume Editor (35)

SPIE Conference Volume | 11 May 2023

Women in Optics and Photonics in India 2022

SPIE Conference Volume | 24 March 2020

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII

SPIE Conference Volume | 4 April 2019

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII

SPIE Conference Volume | 14 May 2018

Biomedical Vibrational Spectroscopy 2018: Advances in Research and Industry

SPIE Conference Volume | 7 May 2018

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI

Showing 5 of 35 publications

Conference Committee Involvement (69)

Women in Optics and Photonics in India 2023

2 January 2024 | Chennai, India

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables IV

28 January 2023 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2023

28 January 2023 | San Francisco, California, United States

Women in Optics and Photonics in India 2022

6 December 2022 | Bangalore, India

SPIE/COS Photonics Asia Digital Forum

5 December 2022 | Online Only, China

Advanced Chemical Microscopy for Life Science and Translational Medicine 2022

23 January 2022 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX

23 January 2022 | San Francisco, California, United States

Multiscale Imaging and Spectroscopy III

22 January 2022 | San Francisco, California, United States

Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry

22 January 2022 | San Francisco, California, United States

Optics and Biophotonics in Low-Resource Settings VIII

22 January 2022 | San Francisco, California, United States

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III

22 January 2022 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2021

6 March 2021 | Online Only, California, United States

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables II

6 March 2021 | Online Only, California, United States

Optics and Biophotonics in Low-Resource Settings VII

6 March 2021 | Online Only, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX

6 March 2021 | Online Only, California, United States

Multiscale Imaging and Spectroscopy II

6 March 2021 | Online Only, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII

2 February 2020 | San Francisco, California, United States

Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry

1 February 2020 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine

1 February 2020 | San Francisco, California, United States

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables

1 February 2020 | San Francisco, California, United States

Optics and Biophotonics in Low-Resource Settings VI

1 February 2020 | San Francisco, California, United States

Multiscale Imaging and Spectroscopy

1 February 2020 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII

3 February 2019 | San Francisco, California, United States

Optics and Biophotonics in Low-Resource Settings V

2 February 2019 | San Francisco, California, United States

Diseases in the Breast and Reproductive System V

2 February 2019 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI

28 January 2018 | San Francisco, California, United States

Optics and Biophotonics in Low-Resource Settings IV

27 January 2018 | San Francisco, California, United States

Biomedical Vibrational Spectroscopy 2018: Advances in Research and Industry

27 January 2018 | San Francisco, California, United States

Diseases in the Breast and Reproductive System IV

27 January 2018 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV

29 January 2017 | San Francisco, California, United States

Diagnosis and Treatment of Diseases in the Breast and Reproductive System III

28 January 2017 | San Francisco, California, United States

Optics and Biophotonics in Low-Resource Settings III

28 January 2017 | San Francisco, California, United States

Neural Imaging and Sensing

15 February 2016 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV

14 February 2016 | San Francisco, California, United States

Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry

13 February 2016 | San Francisco, California, United States

Optics and Biophotonics in Low-Resource Settings II

13 February 2016 | San Francisco, California, United States

Diagnosis and Treatment of Diseases in the Breast and Reproductive System II

13 February 2016 | San Francisco, California, United States

Neurophotonics

9 February 2015 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII

8 February 2015 | San Francisco, California, United States

Optics and Biophotonics in Low-Resource Settings

7 February 2015 | San Francisco, California, United States

Diagnosis and Treatment of Diseases in the Breast and Reproductive System

7 February 2015 | San Francisco, California, United States

Neurophotonics

3 February 2014 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII

2 February 2014 | San Francisco, California, United States

Biomedical Vibrational Spectroscopy VIII: Advances in Research and Industry

1 February 2014 | San Francisco, California, United States

Neurophotonics

4 February 2013 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic Systems XI

3 February 2013 | San Francisco, California, United States

Photons and Neurons IV

23 January 2012 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic Systems X

22 January 2012 | San Francisco, California, United States

Biomedical Vibrational Spectroscopy VII: Advances in Research and Industry

21 January 2012 | San Francisco, California, United States

Photons and Neurons III

24 January 2011 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic Systems IX

23 January 2011 | San Francisco, California, United States

Photons and Neurons II

25 January 2010 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic Systems VIII

24 January 2010 | San Francisco, California, United States

Biomedical Vibrational Spectroscopy VI: Advances in Research and Industry

23 January 2010 | San Francisco, California, United States

Photons and Neurons

26 January 2009 | San Jose, California, United States

Advanced Biomedical and Clinical Diagnostic Systems VII

25 January 2009 | San Jose, California, United States

Optical Interactions with Tissue and Cells XIX

21 January 2008 | San Jose, California, United States

Advanced Biomedical and Clinical Diagnostic Systems VI

20 January 2008 | San Jose, California, United States

Biomedical Vibrational Spectroscopy V: Advances in Research and Industry

19 January 2008 | San Jose, California, United States

Advanced Biomedical and Clinical Diagnostic Systems V

21 January 2007 | San Jose, California, United States

Advanced Biomedical and Clinical Diagnostic Systems IV

22 January 2006 | San Jose, California, United States

Biomedical Vibrational Spectroscopy IV: Advances in Research and Industry

21 January 2006 | San Jose, California, United States

Advanced Biomedical and Clinical Diagnostic Systems III

23 January 2005 | San Jose, CA, United States

Spectral Imaging: Instrumentation, Applications, and Analysis

23 January 2005 | San Jose, CA, United States

Biomedical Vibrational Spectroscopy III: Advances in Research and Industry

25 January 2004 | San Jose, CA, United States

Advanced Biomedical and Clinical Diagnostic Systems

26 January 2003 | San Jose, CA, United States

Spectral Imaging: Instrumentation, Applications, and Analysis

26 January 2003 | San Jose, CA, United States

Biomedical Vibrational Spectroscopy II

19 January 2002 | San Jose, CA, United States

Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques

26 January 2000 | San Jose, CA, United States

Showing 5 of 69 Conference Committees

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