Colorectal cancer is a major health issue worldwide. Conventional white light endoscopy (WLE) coupled to histology is considered as the gold standard today and is the most widespread technique used for colorectal cancer diagnosis. However, during the early stages, colorectal cancer is very often characterized by flat adenomas which develop just underneath the mucosal surface. The use of WLE, which is heavily based on the detection of morphological changes, becomes quite delicate due to subtle or quasi-invisible morphological changes of the colonic lining. Several techniques are currently being investigated in the scope of providing new tools that would allow such a diagnostic or assist actual techniques in so doing. We hereby present a novel technique where high spatial resolution MRI is combined with autofluorescence and reflectance spectroscopy in a bimodal endoluminal probe to extract morphological data and biochemical information, respectively. The design and conception of the endoluminal probe are detailed and the promising preliminary results obtained in vitro (home-built phantom containing eosin and rhodamine B), on an organic sample (the kiwi fruit) and in vivo on a rabbit are presented and discussed.
Conventional white light endoscopy (WLE) is the most widespread technique used today for colorectal cancer diagnosis
and is considered as the gold standard when coupled to biopsy and histology. However for early stage colorectal cancer
diagnosis, which is very often characterised by flat adenomas, the use of WLE is quite difficult due to subtle or quasiinvisible
morphological changes of the colonic lining. Figures worldwide point out that diagnosing colorectal cancer in
its early stages would significantly reduce the death toll all while increasing the 5-year survival rate. Several techniques
are currently being investigated in the scope of providing new tools that would allow such a diagnostic or assist actual
techniques in so doing. We hereby present a novel technique where High spatial Resolution MRI (HR-MRI) is coupled
to optical spectroscopy (autofluorescence and reflectance) in a bimodal endoluminal probe to extract morphological data
and biochemical information respectively. The design and conception of the endoluminal probe along with the
preliminary results obtained with an organic phantom and in-vivo (rabbit) are presented and discussed.
In the light of the bimodal technical innovations put forward in the diagnosis of early stage colorectal
cancer, we present a preliminary study based on a first prototype of a high Resolution MRI-Optics
probe along with the first tests carried out and the results obtained.
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