This paper reports a plasmon-induced photoacoustic transducer for non-invasive skin tightening using a laser diode and an ultrathin nanoplasmonic optical absorber. The nanoplasmonic absorber consists of three-dimensional Au nanoislands (Au NIs) with high optical absorption and polydimethylsiloxane (PDMS) thin film with high thermal expansion coefficient. The low-cost and compact laser diode (LD) significantly scales down the conventional photoacoustic system based on bulk solid-state lasers and excites the nanoplasmonic absorber with sufficient optical energy to generate MHz-scale ultrasound. This plasmon-induced photoacoustic transducer opens new opportunities for ultrasound in dermatology, extending its application to portable at-home skin-care device.
This paper reports a nanoplasmonic isothermal PCR assay with CRISPR/Cas for real-time SARS-CoV-2 detection. The study utilizes a microchip and a miniaturized hand-held type photothermal PCR system, which comprises a nanoplasmonic photothermal heater and microlens array camera to maintain the temperature and detect fluorescence signal from the chip. CRISPR-based fluorescence signal detection, which proceeds simultaneously with nucleic acid amplification, indicates higher sensitivity and rapid detection. The real-time nanoplasmonic isothermal PCR assay opens a new opportunity for POCT-based CRISPR assay.
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