This study aims at evaluating the effect of NeoAdjuvant Chemotherapy (NAC) on the contralateral tumor-free breast tissue through time domain diffuse optical spectroscopy. The breast tissue composition consisting of hemoglobin, water, lipid, and collagen concentrations is quantitatively derived using our seven-wavelength (635-1060 nm) optical mammograph. Preliminary analysis of ten patients' data shows compositional changes occurring in the non-tumor breast in addition to the tumor breast. This includes reduction in breast density and components’ concentrations through the course of the therapy. The final goal is to eventually identify if there is a correlation of these effects with pathological complete response.
The purpose of this clinical study is to monitor NeoAdjuvant Chemotherapy through time domain Diffuse Optical Spectroscopy, correlate the optical results with conventional imaging techniques and pathological response and eventually predict the efficacy of NAC in breast cancer patients. Our seven wavelength (635 -1060 nm) optical mammograph is used to perform non-invasive measurements on patients undergoing NAC in this study. The broad spectral range helps us to fully analyze tissue composition, that includes hemoglobin, water lipids and collagen concentration, to track the tumor response during the course of the therapy. In this paper, we present the preliminary results of five patients.
We present in vivo tests on healthy women through our optical mammograph in preparation for a clinical validation on neoadjuvant chemotherapy monitoring, and we report preliminary data on the first patient enrolled in the study.
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