An image-based low-dose simulation method for CT is presented which does not require raw sinogram data. A virtual
sinogram is generated by performing line integral of the CT
number-based attenuation value using CT scan parameters
available in the literature, and a separate noise sinogram is generated using a noise model which incorporating X-ray
photon flux depending on mAs, system electronic noise, and the virtual sinogram. A synthetic noise CT data is
generated by applying FBP of the noise sinogram using an appropriate filter depending on reconstruction kernel of
original CT. Finally, a simulated low-dose CT image is generated by adding the synthetic noise CT data to the original
CT data.
An anthropomorphic chest phantom was scanned with two different mAs levels(20, 200 mAs), and the developed
method was applied to the highest dose image to simulated lower dose images. Comparison of standard deviation on
selected ROIs showed an acceptable agreement with difference ranging 1.3 to 12.5%, and other texture features
exhibited appreciable differences between the real low-dose and simulated low-dose CT data.
In conclusion, the proposed image-based low-dose CT simulation method might be a useful tool for assessing low-dose
CT application in various clinical settings even when raw sinogram is not available.
Perfusion CT (PCT) examinations are getting more frequently used for diagnosis of acute brain diseases such as
hemorrhage and infarction, because the functional map images it produces such as regional cerebral blood flow (rCBF),
regional cerebral blood volume (rCBV), and mean transit time (MTT) may provide critical information in the emergency
work-up of patient care. However, a typical PCT scans the same slices several tens of times after injection of contrast
agent, which leads to much increased radiation dose and is inevitability of growing concern for radiation-induced cancer
risk. Reducing the number of views in projection in combination of TV minimization reconstruction technique is being
regarded as an option for radiation reduction. However, reconstruction artifacts due to insufficient number of X-ray
projections become problematic especially when high contrast enhancement signals are present or patient's motion
occurred.
In this study, we present a novel reconstruction technique using contrast-adaptive TpV minimization that can reduce
reconstruction artifacts effectively by using different p-norms in high contrast and low contrast objects. In the proposed
method, high contrast components are first reconstructed using thresholded projection data and low p-norm total
variation to reflect sparseness in both projection and reconstruction spaces. Next, projection data are modified to contain
only low contrast objects by creating projection data of reconstructed high contrast components and subtracting them
from original projection data. Then, the low contrast projection data are reconstructed by using relatively high p-norm
TV minimization technique, and are combined with the reconstructed high contrast component images to produce final
reconstructed images.
The proposed algorithm was applied to numerical phantom and a clinical data set of brain PCT exam, and the resultant
images were compared with those using filtered back projection (FBP) and conventional TV reconstruction algorithm.
Our results show the potential of the proposed algorithm for image quality improvement, which in turn may lead to dose
reduction.
This paper presents an automated scheme for breast density estimation on mammogram using statistical and boundary
information. Breast density is regarded as a meaningful indicator for breast cancer risk, but measurement of breast
density still relies on the qualitative judgment of radiologists. Therefore, we attempted to develop an automated system
achieving objective and quantitative measurement. For preprocessing, we first segmented the breast region, performed
contrast stretching, and applied median filtering. Then, two features were extracted: statistical information including
standard deviation of fat and dense regions in breast area and boundary information which is the edge magnitude of a set
of pixels with the same intensity. These features were calculated for each intensity level. By combining these features,
the optimal threshold was determined which best divided the fat and dense regions. For evaluation purpose, 80 cases of
Full-Field Digital Mammography (FFDM) taken in our institution were utilized. Two observers conducted the
performance evaluation. The correlation coefficients of the threshold and percentage between human observer and
automated estimation were 0.9580 and 0.9869 on average, respectively. These results suggest that the combination of
statistic and boundary information is a promising method for automated breast density estimation.
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