Prof. Christoph Hock Profile

Prof. Christoph Hock

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 24 May 2022 Presentation + Paper

Noninvasive optoacoustic imaging of the human brain validated with magnetic resonance angiography

Ruiqing Ni, Xosé Luís Deán-Ben, Valarie Treyer, Jan Klohs, Anton Gietl, Christoph Hock, Roger Nitsch, Daniel Razansky

Proceedings Volume 12146, 1214603 (2022) https://doi.org/10.1117/12.2619536

KEYWORDS: Neuroimaging, Brain, Magnetic resonance imaging, Optoacoustics

Read Abstract +

Imaging modalities capable of visualizing the human brain have led to major advances in neuroscience. Functional magnetic resonance imaging has enabled a better understanding of brain function and connectivity abnormalities in brain diseases and has become a workhorse in neuroimaging. Nuclear imaging technologies such as positron emission tomography and single-photon emission computed tomography assisted with radiolabelled tracers have further enabled molecular diagnosis and monitoring of brain diseases. Limitations of these established technologies, such as the high cost or the use of ionizing radiation as well as accessibility, have fostered the development of new imaging approaches that can complement or enhance their performance. Optoacoustic tomography (OAT) provides unique capabilities to study cerebral function by mapping changes in several hemodynamic parameters within the brain. It further provides molecular imaging capabilities that can facilitate disease diagnosis and treatment monitoring. However, OAT imaging of the human brain is severely hampered by acoustic attenuation and aberrations of ultrasound waves propagating through the skull. Herein, we performed transcranial OAT imaging through the temporal bone of an adult healthy volunteer based on a previously reported spherical ultrasound array. We validated the OAT results by using head-to-head time-of-flight (TOF) magnetic resonance angiography (MRA) and T1-weighted structural MRI. The superior middle cerebral vein in the temporal cortex was identified in the OAT images matching the observed location in TOF-MRA. This basic demonstration anticipates the development of new hardware and reconstruction algorithms, ultimately enabling accurate OAT imaging of the human brain cortex.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years