Sensorineural hearing loss (SNHL) is the most common sensory problem that causes permanent hearing loss due to the damage of cochlear hair cells. Current clinical imaging techniques do not provide sufficient resolution and functional assessment of the intracochlear structures. We developed a dual-mode endoscopic system that combines optical coherence tomography and autofluorescence to visualize the morphology and biochemical changes of the intracochlear structures. The preclinical assessment of the system was performed in a ovine model of SNHL in vivo. The preliminary results suggest that this approach may provide more accurate diagnosis of cochlear pathology and enable targeted SNHL therapies.
KEYWORDS: Ear, Optical coherence tomography, Endoscopy, Auto-fluorescence imaging, In vivo imaging, Magnetic resonance imaging, Pathology, Visualization, Sensors, Bone
This study presents a novel technology for in vivo cochlear imaging in sensorineural hearing loss (SNHL). SNHL is the most common type of permanent hearing loss and is associated with damaged hair cells of the cochlea. State of the art clinical imaging does not have sufficient resolution to show inner ear microstructure. We are developing and testing a dual-modal endoscopic instrument that combines optical coherence tomography (OCT) and autofluorescence imaging (AFI) for dynamic cochlear imaging. If successful, this approach will improve our understanding of the cellular basis of SNHL and enable the development of targeted therapies for inner ear disorders.
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