Mr. Daniel Surinach Profile

Daniel Surinach

at Univ of Minnesota Twin Cities

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Publications (3)

SPIE Journal Paper | 17 January 2025 Open Access

Seizure network characterization by functional connectivity mapping and manipulation

James E. Niemeyer, Peijuan Luo, Carmen Pons, Shiqiang Wu, Hongtao Ma, Jyun-you Liou, Daniel Surinach, Suhasa B. Kodandaramaiah, Theodore H. Schwartz

NPh, Vol. 12, Issue S1, S14605, (January 2025) https://doi.org/10.1117/12.10.1117/1.NPh.12.S1.S14605

KEYWORDS: Ablation, Brain, Calcium, Epilepsy, Brain mapping, Cobalt, Animals, Anatomy, Neurophotonics, Electrodes

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SignificanceDespite the availability of various anti-seizure medications, nearly 1/3 of epilepsy patients experience drug-resistant seizures. These patients are left with invasive surgical options that do not guarantee seizure remission. The development of novel treatment options depends on elucidating the complex biology of seizures and brain networks.AimWe aimed to develop an experimental paradigm that uses anatomical network information, functional connectivity, and in vivo seizure models to determine how brain networks, and their manipulation, affect seizure propagation.ApproachGuided by a known anatomical network, we applied widefield calcium imaging to determine how neural activity and seizures spread through the network regions, focusing on the primary somatosensory cortex and secondary motor cortex. We used in vivo microstimulation to induce suprathreshold excitatory activation and compared this reproducible stimulus with acute pharmacologically induced spontaneous seizure propagation. In a proof-of-concept experiment, we ablated a single node within this bilateral network and measured the effect on propagation and recruitment. Similar preliminary experiments were repeated in a chronic seizure model.ResultsThe microstimulation of the somatosensory cortex propagated in a distinct pattern throughout the bilateral network with sequential reproducible node recruitment. Seizures recapitulated this same pattern, indicating a hijacking of existing pathways. Ablation of a key node in the network in the secondary motor cortex changed contralateral spread. Early chronic cobalt seizure data are presented.ConclusionHere, we demonstrate a paradigm for combining widefield calcium imaging with microstimulation, cortical ablation, and seizure mapping to determine how anatomical networks inform the propagation patterns of cortical seizures. These experiments can be extended to long-term tracking of epilepsy to study epileptogenesis in other cortical networks. Our proof-of-concept findings suggest that this paradigm may be useful in the development of novel therapies for drug-resistant epilepsy patients and can be extended to the study of other disorders involving brain networks.

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SPIE Journal Paper | 26 September 2024 Open Access

Computer vision–guided open-source active commutator for neural imaging in freely behaving animals

Ibrahim Oladepo, Kapil Saxena, Daniel Surinach, Malachi Lehman, Suhasa Kodandaramaiah

NPh, Vol. 11, Issue 03, 034312, (September 2024) https://doi.org/10.1117/12.10.1117/1.NPh.11.3.034312

KEYWORDS: Head, Video, Miniaturization, Animals, Calcium, Neurophotonics, Education and training, Animal model studies, Data acquisition, Cameras

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Proceedings Article | 21 February 2020 Presentation + Paper

Miniaturized device for whole cortex mesoscale imaging in freely behaving mice

Mathew Rynes, Daniel Surinach, Micheal LaRoque, Samantha Linn, Judith Dominguez, Leila Ghanbari, Suhasa Kodandaramaiah

Proceedings Volume 11226, 112260G (2020) https://doi.org/10.1117/12.2550395

KEYWORDS: Video, Brain, Image resolution, Calcium, Skull, Polymers, Neuroimaging

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