KEYWORDS: Wavelets, Image restoration, Magnetic resonance imaging, Image quality, Signal detection, Modeling, Performance modeling, Data modeling, Signal to noise ratio, Medical image reconstruction
PurposeTask-based assessment of image quality in undersampled magnetic resonance imaging provides a way of evaluating the impact of regularization on task performance. In this work, we evaluated the effect of total variation (TV) and wavelet regularization on human detection of signals with a varying background and validated a model observer in predicting human performance.ApproachHuman observer studies used two-alternative forced choice (2-AFC) trials with a small signal known exactly task but with varying backgrounds for fluid-attenuated inversion recovery images reconstructed from undersampled multi-coil data. We used a 3.48 undersampling factor with TV and a wavelet sparsity constraints. The sparse difference-of-Gaussians (S-DOG) observer with internal noise was used to model human observer detection. The internal noise for the S-DOG was chosen to match the average percent correct (PC) in 2-AFC studies for four observers using no regularization. That S-DOG model was used to predict the PC of human observers for a range of regularization parameters.ResultsWe observed a trend that the human observer detection performance remained fairly constant for a broad range of values in the regularization parameter before decreasing at large values. A similar result was found for the normalized ensemble root mean squared error. Without changing the internal noise, the model observer tracked the performance of the human observers as the regularization was increased but overestimated the PC for large amounts of regularization for TV and wavelet sparsity, as well as the combination of both parameters.ConclusionsFor the task we studied, the S-DOG observer was able to reasonably predict human performance with both TV and wavelet sparsity regularizers over a broad range of regularization parameters. We observed a trend that task performance remained fairly constant for a range of regularization parameters before decreasing for large amounts of regularization.
Task-based assessment of image quality in undersampled magnetic resonance imaging (MRI) using constraints is important because of the need to quantify the effect of the artifacts on task performance. Fluid-attenuated inversion recovery (FLAIR) images are used in detection of small metastases in the brain. In this work we carry out two-alternative forced choice (2-AFC) studies with a small signal known exactly (SKE) but with varying background for reconstructed FLAIR images from undersampled multi-coil data. Using a 4x undersampling and a total variation (TV) constraint we found that the human observer detection performance remained fairly constant for a broad range of values in the regularization parameter before decreasing at large values. Using the TV constraint did not improve task performance. The non- prewhitening eye (NPWE) observer and sparse difference-of-Gaussians (S-DOG) observer with internal noise were used to model human observer detection. The parameters for the NPWE and the internal noise for the S-DOG were chosen to match the average percent correct (PC) in 2-AFC studies for three observers using no regularization. The NPWE model observer tracked the performance of the human observers as the regularization was increased but slightly over-estimated the PC for large amounts of regularization. The S-DOG model observer with internal noise tracked human performace for all levels of regularization studied. To our knowledge this is the first time that model observers have been used to track human observer detection for undersampled MRI.
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