Chronic hyperglycemia is the pathogenetic basis of the occurrence and development of macro- and microvascular disorders in diabetes mellitus (DM). The drug liraglutide is widely used to correct the glycemic profile in diabetic patients. The method of laser Doppler flowmetry (LDF) was used to study microcirculation disorders in rats caused by alloxan diabetes, as well as the state of the microvasculature against the background of hyperglycemia correction with liraglutide. Disturbance of microcirculation (MC) was manifested by a decrease in the perfusion index on the skin of the dorsum of the foot in combination with a decrease in the normalized amplitudes of endothelial and neurogenic fluctuations. In animals that underwent correction of hyperglycemia with liraglutide, stimulation of endotheliumdependent vasodilation and normalization of neurogenic vascular tone of the precapillary link were observed, which contributed to the restoration of impaired microcirculation of the hindpaw skin in rats with alloxan diabetes. Also, liraglutide caused a decrease in the concentration of markers of endothelial dysfunction (ED) in the blood serum and in the level of catecholamines (CA) relative to animals in the comparison group. Liraglutide contributed to the normalization of the serum concentration of vasculoendothelial growth factor (VEGF), the increased level of which indicated the inflammatory activation of endothelial cells.
Chronic hyperglycemia in diabetes mellitus (DM) is the pathogenetic basis for the occurrence and development of macro- and microvascular disorders, which provoke the development of retinopathy, nephropathy and cause the accelerated development of atherosclerosis with damage to the coronary, cerebral and peripheral vessels. This determines the relevance of developing new methods for the correction of disorders of carbohydrate metabolism, including nonpharmacological ones. Using the method of laser Doppler flowmetry, microcirculation disorders in rats caused by alloxan insulin deficiency were studied. Disruption of microcirculation was manifested by a decrease in perfusion index on the skin of the dorsum of the foot in combination with a decrease in the normalized amplitudes of endothelial and neurogenic oscillations. An animals that have non-pharmacological correction (autotransplantation of the skin flap) of carbohydrate metabolism disorders, an increase in perfusion index relative to the comparison group was observed on day 42 of the experiment, indicating an improvement in microcirculation. An increase in the normalized amplitudes of endothelial and neurogenic oscillations relative to the comparison group was also noted. The data obtained allow us to conclude that the use of laser Doppler fluometry in the study of the functional state of the microvasculature and the diagnosis of vascular complications of diabetes is very promising.
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