F. Hanton, D. Doria, K. Kakolee, S. Kar, S. Litt, F. Fiorini, H. Ahmed, S. Green, J. C. Jeynes, J. Kavanagh, D. Kirby, K. J. Kirkby, C. Lewis, M. Merchant, G. Nersisyan, R. Prasad, K. Prise, G. Schettino, M. Zpef, M. Borghesi
The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton
therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating
the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short
duration resulting in ultra-high dose rates, and an investigation at Queen’s University Belfast was carried out to
investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing
protons in the MeV range for proton irradiation, with dose rates exceeding 109 Gys-1 on a single exposure. A clonogenic
assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data
obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant
difference. A Relative Biological effectiveness of 1.4±0.2 at 10 % Survival Fraction was estimated from a comparison
with a 225 kVp X-ray source.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.