While laser can acquire ultra-high-resolution image at desired area, the penetration depth of light is limited due to tissue scattering, making it difficult to reach deep depths. For this, we previously proposed a technique that uses ultrasonic energy to temporarily generate bubbles in the ultrasonic path to suppress scattering and increase the penetration depth. However, it is hard to accurately create bubbles in a preferred position due to randomly generated within the depth of focus. In this study, we introduce a Laser-induced bubble generation technique combined with ultrasound that can make bubbles at precise locations while maintaining high light transmittance.
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