Mr. Hiep M. Ha Profile

Hiep M. Ha

at Japan Advanced Institute of Science and Technology

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Proceedings Article | 11 October 2007 Paper

Nanostructure and molecular interface for biosensing devices

Hiep Ha, Tatsuro Endo, Do-Kyun Kim, Eiichi Tamiya

Proceedings Volume 6768, 67680I (2007) https://doi.org/10.1117/12.735945

KEYWORDS: Nanostructures, Sensors, Proteins, Nanoparticles, Absorbance, Gold, Microfluidics, Biosensing, Nanolithography, Interfaces

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Nanostructure and molecular interface have currently received the great attractions for highly efficient, simultaneously analysis of a number of important biomolecules from proteomics to genomics. Outstanding optical property of noble metal nanostructures, localized surface plasmon resonance (LSPR), is a powerful phenomenon used in many chemical and biological sensing experiments. This report described two types of gold-capped nanostructures: nanoparticle and nanopore which reveal the strong excitation of LSPR spectra in the UV-visible region. The optical absorbance properties of these nanostructures governing its sensitivity to local environment were studied. The flexibility in design of the goldcapped nanostructures was evidently displayed on the wide-range capacity to develop in many types, from single to multiple to microfluidic formats. Moreover, chemical modifications on the nanostructure surface were thoroughly exploited to archive a highly sensitive protein and gene sensors such as using Protein A linker for orientation antibody or using specific binding of streptavidin and biotinylated PNA or DNA probes... Lastly, we introduced a new form of optical sensor, involving the coupling between interferometry and LSPR properties on the surface of gold-capped nanopore structure. Our optical biosensing devices connecting with the gold-capped nanostructures including both nanoparticle and nanopore are applicable to highly sensitive monitoring the interactions of other biomolecules, such as proteins, whole cells, or receptors with a massively parallel detection capability in a highly miniaturized package.

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