We demonstrate simultaneous multi-band spatial frequency domain imaging (SFDI) and blood flow mapping by multi-exposure laser speckle contrast imaging (MELSCI) with a laboratory-designed 2x2-aperture 4-tap CMOS image sensor. The proposed imaging device is composed of an array of sub-image sensors. This multi-aperture configuration realizes multi-wavelength imaging to estimate chromophore concentrations and wavelength-division-multiplexed imaging for multi-band SFDI and MELSCI. For SFDI, 450, 550, 660nm LEDs were used as the light sources of a DMD. For MELSCI, a 785nm LD was used for flood illumination. Reflectance and K2 maps of a human arm before and after an exercise was measured.
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