Mr. Klaus S. Andersen Profile

Klaus S. Andersen

PhD candidate at Danmarks Tekniske Univ

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Proceedings Article | 13 March 2008 Paper

Simulation of microbubble response to ambient pressure changes

Klaus Scheldrup Andersen, Jørgen Arendt Jensen

Proceedings Volume 6920, 692016 (2008) https://doi.org/10.1117/12.773296

KEYWORDS: Acoustics, Ultrasonography, Blood pressure, Computer simulations, Liquids, Motion models, Rectangular pulse, Diagnostics, Arteries, In vivo imaging

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The theory on microbubbles clearly indicates a relation between the ambient pressure and the acoustic behavior of the bubble. The purpose of this study was to optimize the sensitivity of ambient pressure measurements, using the subharmonic component, through microbubble response simulations. The behaviour of two different contrast agents was investigated as a function of driving pulse and ambient overpressure, p_ov. Simulations of Levovist using a rectangular driving pulse show an almost linear reduction in the subharmonic component as p_ov is increased. For a 20 cycles driving pulse, a reduction of 4.6 dB is observed when changing p_ov from 0 to 25 kPa. Increasing the pulse duration makes the reduction even more clear. For a pulse with 64 cycles, the reduction is 9.9 dB. This simulation is in good correspondence with measurement results presented by Shi et al. 1999, who found a linear reduction of 9.6 dB. Further simulations of Levovist show that also the shape and the acoustic pressure of the driving pulse are very important factors. The best pressure sensitivity of Levovist was found to be 0.88 dB/kPa. For Sonazoid, a sensitivity of 0.71 dB/kPa has been found, although the reduction is not completely linear as a function of the ambient pressure.

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