The developed portable multi-spectral photoplethysmograph (MS-PPG) optical biosensor device, intended for analysis of peripheral blood volume pulsations at different vascular depths, has been clinically verified. Multi-spectral monitoring was performed by means of a four – wavelengths (454 nm, 519 nm, 632 nm and 888 nm) light emitted diodes and photodiode with multi-channel signal output processing. Two such sensors can be operated in parallel and imposed on the patient’s skin. The clinical measurements confirmed ability to detect PPG signals at four wavelengths simultaneously and to record temporal differences in the signal shapes (corresponding to different penetration depths) in normal and pathological skin. This study analyzed wavelengths relations between systole and diastole peak difference at various tissue depths in normal and pathological skin. The difference between parameters of healthy and pathological skin at various skin depths could be explain by oxy- and deoxyhemoglobin dominance at different wavelengths operated in sensor. The proposed methodology and potential clinical applications in dermatology for skin assessment are discussed.
Multi-spectral photoplethysmograph biosensor intended for analysis of peripheral blood volume pulsations at different
vascular depths has been experimentally tested. Light emitting diodes with four different wavelengths were used as the
light emitters. A single photodiode with multi-channel signal output processing was used as the light detector. This study
analyzed rising time difference between wavelengths at systole maximum, wavelengths relations between systole and
diastole peak difference. The proposed methodology is discussed.
A portable multi-spectral photoplethysmography device has been used for studies of 40 subjects. Multi-spectral
monitoring was performed by means of a four - wavelengths (465 nm, 530 nm, 630 nm and 870 nm) light emitted diodes
(LED) and a single photodiode with multi-channel signal output processing. The proposed methodology and potential
clinical applications are discussed.
A photoplethysmography (PPG) signal can provide very useful information about a subject's hemodynamic status in a
hospital or home environment. A newly developed portable multi-spectral photoplethysmography device has been used
for studies of 11 healthy subjects. Multi-spectral photoplethysmography (MS-PPG) biosensor intended for analysis of
peripheral blood volume pulsations at different vascular depths has been designed and experimentally tested. Multispectral
monitoring was performed by means of a three-wavelengths (405 nm, 660 nm and 780 nm) laser diode and a
single photodiode with multi-channel signal output processing. The proposed methodology and potential clinical
applications are discussed.
A photoplethysmography (PPG) signal can provide very useful information about a subject's hemodynamic status in a
hospital or home environment. A newly developed portable multi-spectral photoplethysmography device has been used
for studies of 11 healthy subjects. The developed optical fiber biosensor comprises one multi-wavelength laser diode
(405nm, 660nm and 780nm) and a single photodiode with multi-channel signal output processing and built in Li-ion
accumulator; special software was created for visualization and measuring of the MS-PPG signals. ARM7TDMI-S
LPC2148, NXP (founded by Philips) 32 bit processor with clock frequency of 60 MHz performs measurement and
analysis of the signal.
The paper investigates influence and efficacy of laser therapy on pigmented and vascular cutaneous malformations by
multispectral imaging technique. Parameter mapping of skin pigmented and vascular lesions and monitoring of the laser
therapy efficacy are performed by multispectral imaging in wavelength range 450-700nm by scanning step - 10nm.
Parameter maps of the oxyhemoglobin deoxyhemoglobin and melanin derived from the images are presented. Possibility
of laser therapy efficacy monitoring by comparison of the parameter maps before and after laser treatment has been
demonstrated. As both cutaneous pigmented and vascular malformations are commonly found lesions, the parameter
mapping would be a valuable method to use routinely.
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