Prof. Laura Cooper Profile

Prof. Laura Cooper

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Proceedings Article | 5 March 2022 Presentation + Paper

Photonic resonator interferometric scattering microscopy

Nantao Li, Xiaojing Wang, Joseph Tibbs, Taylor Canady, Qinglan Huang, Glenn Fried, Xing Wang, Laura Cooper, Lijun Rong, Yi Lu, Brian Cunningham

Proceedings Volume 12004, 120040K (2022) https://doi.org/10.1117/12.2606436

KEYWORDS: Scattering, Interferometry, Prisms, Microscopy, Light scattering, Viruses, Resonators, Laser scattering, Proteins, Photons

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Interferometric scattering microscopy is a newly emerging alternative to fluorescence microscopy in biomedical research and diagnostic testing due to its ability to detect nano-objects such as individual proteins, extracellular vesicles, and virions individually through their intrinsic elastic light scattering. To improve the signal-to-noise ratio, we developed photonic resonator interferometric scattering microscopy (PRISM) in which a photonic crystal (PC) resonator is used as the sample substrate. The scattered light is amplified by the PC through resonant near-field enhancement, which then interferes with the <1% transmitted light to create intensity contrast. Importantly, the scattered photons assume the wavevectors defined by PC’s photonic band structure, resulting in the ability to utilize a non-immersion objective without significant loss at illumination density as low as 25 W/cm². We demonstrate virus and protein detection, including highly selective capture and counting of intact pseudotype SARS-CoV-2 from saliva with sensitivity equivalent to conventional nucleic acid tests. The results showcase the promise of nanophotonic surfaces in the development of resonance-enhanced interferometric microscopies, and as a single step, room temperature, and rapid viral detection technology.

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