Asymmetry of bilateral cerebral function, i.e. laterality, is an important phenomenon in many brain
actions such as motor functions. This asymmetry maybe altered in some clinical conditions such as
Multiple Sclerosis (MS). The aim of this study was to delineate the laterality differences for upper and
lower limbs in healthy subjects to compare this pattern with subjects suffering from MS in advance. Hence
9 Male healthy subjects underwent fMRI assessment, while they were asked to move their limbs in a
predetermined pattern. The results showed that hands movement activates the brain with a significant
lateralization in pre-motor cortex in comparison with lower limb. Also, dominant hands activate brain more
lateralized than the non-dominant hand. In addition, Left basal ganglia were observed to be activated
regardless of the hand used, While, These patterns of Brain activation was not detected in lower limbs. We
hypothesize that this difference might be attributed to this point that hand is usually responsible for precise
and fine voluntary movements, whereas lower limb joints are mainly responsible for locomotion, a function
integrating voluntary and automatic bilateral movements.
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