Dr. Naoharu Kobayashi Profile

Dr. Naoharu Kobayashi

at Univ of Minnesota

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Proceedings Article | 17 March 2015 Paper

3D cine magnetic resonance imaging of rat lung ARDS using gradient-modulated SWIFT with retrospective respiratory gating

Naoharu Kobayashi, Jianxun Lei, Lynn Utecht, Michael Garwood, David Ingbar, Maneesh Bhargava

Proceedings Volume 9417, 941718 (2015) https://doi.org/10.1117/12.2081757

KEYWORDS: Lung, Magnetic resonance imaging, Tissues, Modulation, 3D image processing, Image registration, 3D acquisition, Data acquisition, Image processing, Magnetism

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SWeep Imaging with Fourier Transformation (SWIFT) with gradient modulation and DC navigator retrospective gating is introduced as a 3D cine magnetic resonance imaging (MRI) method for the lung. In anesthetized normal rats, the quasi-simultaneous excitation and acquisition in SWIFT enabled extremely high sensitivity to the fast-decaying parenchymal signals (TE=~4 μs), which are invisible with conventional MRI techniques. Respiratory motion information was extracted from DC navigator signals and the SWIFT data were reconstructed to 3D cine images with 16 respiratory phases. To test this technique’s capabilities, rats exposed to > 95% O₂ for 60 hours for induction of acute respiratory distress syndrome (ARDS), were imaged and compared with normal rat lungs (N=7 and 5 for ARDS and normal groups, respectively). SWIFT images showed lung tissue density differences along the gravity direction. In the cine SWIFT images, a parenchymal signal drop at the inhalation phase was consistently observed for both normal and ARDS rats due to lung inflation (i.e. decrease of the proton density), but the drop was less for ARDS rats. Depending on the respiratory phase and lung region, the lungs from the ARDS rats showed 1-24% higher parenchymal signal intensities relative to the normal rat lungs, likely due to accumulated extravascular water (EVLW). Those results demonstrate that SWIFT has high enough sensitivity for detecting the lung proton density changes due to gravity, different phases of respiration and accumulation of EVLW in the rat ARDS lungs.

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