Prolonged cardiopulmonary bypass (CPB) exposure and excessive anticoagulation during cardiac surgical procedures frequently cause acute bleeding. Here we investigated the accuracy and precision of a novel optical sensor, iCoaglab, that utilizes a small volume of whole blood to comprehensively monitor blood coagulation in patients. Our results showed coagulation metrics, activated clotting times (ACT), maximum clot stiffness (MA), and fibrinolysis were highly correlated with standard-reference tests. In conclusion, iCoaglab uniquely affords comprehensive profiling of whole blood coagulation, potentially enabling the capability to identify coagulation impairments and predict bleeding during CPB.
Real-time monitoring of a patient’s biofluids such as blood, platelets, urine, serum, teardrops, etc. is critical for healthcare professionals who need a fast, low-cost, and easy way to measure key biomarkers at the point of care. Therefore, having a reliable, accurate, and inexpensive on-chip mixer that is capable of passively mixing any biofluid with necessary reagents is vital in order to monitor these parameters, especially in remote areas where access to high-tech or specialized lab equipment might be limited. In this work, we discuss the design, development, and testing of 3D printed passive micromixers capable of successfully performing biofluid mixing in under 5s. Our work presents a novel 3D printed micromixer for rapid and low-cost passive biofluid mixing that has the potential of advancing novel point-of-point care diagnostics
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