Mr. Samir El ketara Profile

Samir El ketara

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 28 February 2020 Paper

Time course study of a gold nanoparticle contrast agent

Samir El ketara, Nancy Ford

Proceedings Volume 11317, 113171O (2020) https://doi.org/10.1117/12.2549803

KEYWORDS: Gold, Nanoparticles, Image contrast enhancement, In vivo imaging, Microcomputed tomography, Cardiac imaging, Vascular imaging, Time series analysis

Read Abstract +

Increasing interest in in vivo preclinical imaging has made micro-computed tomography (micro-CT) a powerful research tool for studying tissue morphology and monitoring disease status in rodents. Although, micro-CT images have high contrast for bone, the contrast between various soft tissues is typically low. To overcome this inherent issue, attenuating exogenous contrast agents are used which allows contrast enhancement in vascular and abdominal organs. The aim of this study is to determine the time course of computed tomography (CT) contrast enhancement of a gold nanoparticle bloodpool contrast agent. Six healthy female C57BL/6 mice were anesthetized and imaged after receiving an injected dose of MVivo™ gold nanoparticle blood-pool contrast agent. Micro-CT scans were acquired at 0, 0.25, 0.5, 0.75, 1, 2, 4, 8, 24, 48 and 72 hours after injection. The mean CT number was determined in a region of interest in 7 organs. No contrast enhancement was noticed in the bladder, kidneys or muscle. However, it clearly appears that the contrast enhancement is high in both right ventricle and vena cava, even with a low dose of contrast agent. A single injection of the blood-pool contrast agent can be used for investigations of cardiac or vascular disease. An optimal cardiac imaging window during the first hour after injection has been determined. Furthermore, the long-lasting contrast enhancement can be very useful when using protocols that require long acquisition times.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years