Dr. Sang-Ho Ye Profile

Dr. Sang-Ho Ye

at Univ. of Pittsburgh Medical Ctr.

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Proceedings Article | 9 May 2024 Presentation + Paper

A novel in situ hemocompatibility enhancement in endovascular devices through arterial pulsation-driven surface modification

Mohamed Ibrahim, Sang-Ho Ye, William Wagner, Youngjae Chun

Proceedings Volume 12948, 1294803 (2024) https://doi.org/10.1117/12.3009999

KEYWORDS: Scanning electron microscopy, Blood, Arteries, Piezoelectric materials, Biological samples, In vitro testing, Batteries, Particles, Heart, Energy harvesting

Read Abstract +

Small artery-related diseases affecting coronary, cerebral, or peripheral regions remain a persistent clinical challenge, primarily due to the enduring risk of thrombosis associated with implanted vascular devices. Despite advances in therapeutic strategies, including the utilization of drug-eluting stents (DES), life-threatening complications, such as late thrombosis, continue to affect patients, leading to severe consequences like heart attacks, strokes, and pulmonary embolisms. To address this critical issue, an innovative in-situ piezoelectric material-based surface treatment system that utilizes arterial pulsation has been studied to treat the surface using arterial pulsation actively and continuously for indwelling endovascular devices. Our novel technology leverages piezoelectric materials to generate a negatively charged surface using arterial pulsation without any battery, actively and effectively repelling platelets adherence to prevent potential clot formation. Hence, substantial reduction in platelet adherence is expected to significantly lower the risk of thrombosis. In this study, a low-profile piezoelectric unit was fabricated and mounted on the coronary artery stent to be deployed and continuously exposed to the blood to assess the device hemocompatibility response, considering typical arterial pulsation, and both circumferential and radial deformation of the endovascular devices. Given the feasibility of achieving platelet-repelling voltages, the pulsation based piezoelectric system presents a promising solution for reducing the platelet adherence in indwelling endovascular devices without the need for passive coating or batteries, which enhances the overall effectiveness of endovascular devices.

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