Pancreatic cancer and colon cancer metastasis are recalcitrant cancers that are often difficult to detect. Mucin 5AC (MUC5A) and Mucin 4 (MUC4) have been found to be overexpressed in pancreatic and colon cancers, respectively, while having minimal expression in normal tissue. Using Mucin antibodies conjugated to a fluorescent dye, we demonstrate their specific labeling of human derived pancreatic and colon cancers in both subcutaneous and orthotopic mouse models. Tumor-specific fluorescent antibodies are clinically promising tools for improving both oncologic resection and patient survival.
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