Prof. Yaling Han Profile

Prof. Yaling Han

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Proceedings Article | 11 September 2024 Open Access

Effect of fat layer thickness on the ablation area in pulsed electric field ablation

Zhen Wang, Ming Liang, Jingyang Sun, Jie Zhang, Yunhao Li, Lisheng Xu, Yaling Han

Proceedings Volume 13270, 132701D (2024) https://doi.org/10.1117/12.3047868

KEYWORDS: Ablation, 3D modeling, Electric fields, Computer simulations, Atrial fibrillation

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Background: Pulsed electric field (PEF) ablation has recently been applied by researchers in the treatment of atrial fibrillation (AF), which is able to utilize high-voltage electric fields to produce damage to the myocardium for the purpose of treating AF. The effect of epicardial fat layer on the ablation effect has not been systematically studied. The purpose of our study was to establish a computer simulation model to rationally simplify the human organ, which was used to evaluate the effect of the fat layer on the ablation damage area. Methods: Firstly, by building a computational simulation model, different tissues of the heart were simplified and a three-dimensional computational model containing only the ablation device of interest was built, the ablation damage range was assessed in the post-processing interface using an electric field threshold of 400v/cm, and finally, the thickness of the fat layer was varied in order to assess the effect of the fat layer on the ablation area. Results: The epicardial fat layer had a weakening effect on PFA, and the total ablation depth decreased when the thickness of the fat layer increased, and when the fat layer reached 1.5 mm, the total ablation depth stabilized and the ablation depth of the myocardial layer decreased. In addition, we found a strong linear relationship between the total ablation depth and pulse voltage.

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