KEYWORDS: Point-of-care devices, Pathogens, Wound healing, Photodynamic therapy, Medicine, Light emitting diodes, Laser systems engineering, LED lighting, In vivo imaging, In vitro testing
We developed a wearable antimicrobial photodynamic therapy (aPDT) device that can sterilize multidrug-resistant (MDR) wound infections safely and effectively at the point of care. This aPDT platform was developed by leveraging advanced optical device fabrication techniques and evaluated by a combination of in vitro, ex vivo, and in vivo bacterial wound infection models. Throughout all the wound infection models, this aPDT platform is capable to inactivate at least 90% of MDR pathogens in the wound infections, showing potential to generalize the application of aPDT in the clinic for MDR infection prevention and treatment for chronic wounds.
Rapid and accurate diagnosis and subtyping of bacterial carbapenemases are urgently needed due to the increasing prevalence of carbapenem-resistant bacterial infections. By mixing bacteria with a fluorescent probe, β-LEAF (β-lactamase enzyme activated fluorophore), together with three β-lactamase inhibitors ( imipenem for noncarbapenemase β-lactamases, clavulanic acid for type A carbapenemases, and EDTA for type B carbapenemase), we developed a FIBA (Fluorescence Identification of β-Lactamase Activity) platform, which can generate a 95% - 100% sensitivity and specificity for carbapenemase diagnosis and classification within 10 minutes by a single mixing step. FIBA could significantly aid the control and treatment of carbapenem-resistant bacterial infections.
Conference Committee Involvement (4)
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2025
27 January 2025 | San Francisco, California, United States
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024
29 January 2024 | San Francisco, California, United States
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2023
28 January 2023 | San Francisco, California, United States
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2022
21 February 2022 | San Francisco, California, United States
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